Validação do "bilicheck" para dosagem de bilirrubina em neonatos / Validation of "bilicheck" for bilirubin measurement in newborns

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Aim: To compare transcutaneous bilirubin m easurement determined by ?Bilicheck®? with capillary serum measurement determined by ?U nistat-Leica Bilirubinometer? in newborns. Methods: A total of 200 newborns were included. For each one, paired measurements (serum, with ?Unistat-Leica Bilirubinometer? and transcutaneous, with ?Bilicheck®? were performed. Their correlation and agreement were analyzed and it was verified the influence of birth weight, race, gestational age, postnat al age and use of phototherapy. We also tried to establish cutoff points in ?Unistat-Leica Bilirubinometer? measurements to access the sensibility and specificity of the ?Bilicheck®? in the critic levels of bilirrubin that are considered for indication of treatments. Results: The linear correlation was 0.92 ( p=0.0001), the average difference between the measurements was 0.72 (± 1.57) mg/dl, with a confidence interval of 95% from -2.42 to +3.86 mg/dl. The only variable that exhi bited a small statistical difference (p=0.003) was postnatal age of less than 3 days. Considering the ?Bilirubin ometer Unistat-Leica? as gold standard, a series of ROC curves were constr ucted revealing that the best cutoff point was at 14 mg/dl with sensitivity of 88.2%, specifi city of 97.8%, positive predictive value of 78.9% and negative predictive value of 98.9% and the area under the curve was 0.98. Conclusion: The ?Bilicheck®? may substitute th e capillary serum measurement until the value of 14 mg/dl. Above this level, it should be considered as a screening test selecting patients that must be submitted to serum measurement

ASSUNTO(S)

hiperbilirrubinemia - diagnostico ictericia hyperbilirubinemia jaundice

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