Varicella-zoster virus complements herpes simplex virus type 1 temperature-sensitive mutants.
AUTOR(ES)
Felser, J M
RESUMO
Varicella-zoster virus (VZV) can complement temperature-sensitive mutants of herpes simplex virus. Of seven mutants tested, two, carrying mutations in the immediate-early ICP4 and ICP27 proteins, were complemented. This complementation was not seen in coinfections with adenovirus type 5 or cytomegalovirus. Following transfection into CV-1 cells, a DNA fragment containing the VZV short repeat sequence complemented the ICP4 mutant. These data demonstrate a functional relationship between VZV and herpes simplex virus and have allowed localization of a putative VZV immediate-early gene.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=255249Documentos Relacionados
- Varicella-zoster virus gene 51 complements a herpes simplex virus type 1 UL9 null mutant.
- Inhibition of herpes simplex virus type 1 replication in temperature-sensitive cell cycle mutants.
- DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.
- Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.
- Specificity of skin test with varicella-zoster virus antigen in varicella-zoster and herpes simplex virus infections.
