Vectorial expansion of the involucrin gene and the relatedness of the hominoids.
AUTOR(ES)
Djian, P
RESUMO
In higher primates, the coding region of the gene for involucrin, an epidermal protein, is mostly composed of a recently generated (modern) segment of repeats of a sequence of 10 codons. While the rest of the coding region has evolved only by nucleotide substitutions, the modern segment has evolved by successive addition of repeats. This process has not taken place randomly; instead, the expansion of the modern segment has been progressive from 3' to 5' end, thus adding vectorially regions that have been defined as early, middle, and late. The relatedness of the human, chimpanzee, and gorilla may be analyzed with greatest sensitivity by comparing their middle regions. The chimpanzee involucrin gene is more closely related to that of the gorilla than to that of the human.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=298299Documentos Relacionados
- Divergent evolution of part of the involucrin gene in the hominoids: unique intragenic duplications in the gorilla and human.
- Involucrin gene of tarsioids and other primates: alternatives in evolution of the segment of repeats.
- Expansion of the Hox gene family and the evolution of chordates.
- Vectorial Metabolism and the Evolution of Transport Systems†
- Expansion of the myotonic dystrophy gene in Italian and Spanish patients.