Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression
AUTOR(ES)
Mok, Kenny C.
FONTE
Oxford University Press
RESUMO
In a process called quorum sensing, bacteria communicate with one another by exchanging chemical signals called autoinducers. In the bioluminescent marine bacterium Vibrio harveyi, two different auto inducers (AI-1 and AI-2) regulate light emission. Detection of and response to the V.harveyi autoinducers are accomplished through two two-component sensory relay systems: AI-1 is detected by the sensor LuxN and AI-2 by LuxPQ. Here we further define the V.harveyi quorum-sensing regulon by identifying 10 new quorum-sensing-controlled target genes. Our examination of signal processing and integration in the V.harveyi quorum-sensing circuit suggests that AI-1 and AI-2 act synergistically, and that the V.harveyi quorum-sensing circuit may function exclusively as a ‘coincidence detector’ that discriminates between conditions in which both autoinducers are present and all other conditions.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145445Documentos Relacionados
- Three Parallel Quorum-Sensing Systems Regulate Gene Expression in Vibrio harveyi†
- Lead Precipitation by Vibrio harveyi: Evidence for Novel Quorum-Sensing Interactions
- Quorum Sensing Regulates Type III Secretion in Vibrio harveyi and Vibrio parahaemolyticus
- Sequence and Function of LuxU: a Two-Component Phosphorelay Protein That Regulates Quorum Sensing in Vibrio harveyi
- Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi.