Viral Events Necessary for the Induction of Interferon in Chick Embryo Cells 1
AUTOR(ES)
Lockart, R. Z.
RESUMO
Temperature-sensitive mutants of Sindbis virus were employed to investigate the nature of the viral event(s) which induces chick-embryo cells to produce interferon. Chick embryo cells induced by the parental heat-resistant strain of Sindbis virus produced essentially equal amounts of interferon at 29 and 42 C. An RNA− and three RNA+ strains [temperature-sensitive mutants unable (RNA−) and able (RNA+) to make ribonucleic acid] produced interferon at 29 C but not at 42 C. It is concluded that viral RNA per se and the replication of viral RNA do not induce interferon production by chick embryo cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=375424Documentos Relacionados
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