Virulence of tissue culture-propagated canine distemper virus.
AUTOR(ES)
Metzler, A E
RESUMO
Virulence of canine distemper virus (CDV) adapted to in vitro growth in Vero or bovine cells was determined by inoculation into CDV-susceptible neonatal gnotobiotic dogs. When compared with dogs given virulent R252-CDV, Vero R252-CDV was attenuated at passage level 14. In contrast, dogs inoculated with bovine R252-CDV at the same passage level experienced rapid fatal neurological disease. Virulence was not linked to ability to infect or replicate in canine pulmonary macrophage cultures. Retention of virulence by bovine R252-CDV is unique and worthy of further study.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551221Documentos Relacionados
- Ultrastructural study of long-term canine distemper virus infection in tissue culture cells.
- A Ferret Model of Canine Distemper Virus Virulence and Immunosuppression
- Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus.
- Antiviral antibodies stimulate production of reactive oxygen species in cultured canine brain cells infected with canine distemper virus.
- CD9, a tetraspan transmembrane protein, renders cells susceptible to canine distemper virus.