Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
AUTOR(ES)
Ruedl, Christiane
FONTE
American Society for Microbiology
RESUMO
Virus-like particles (VLPs) are able to induce cytotoxic T-cell responses in the absence of infection or replication. This makes VLPs promising candidates for the development of recombinant vaccines. However, VLPs are also potent inducers of B-cell responses, and it is generally assumed that such VLP-specific antibodies interfere with the induction of protective immune responses, a phenomenon summarized as carrier suppression. In this study, we investigated the impact of preexisting VLP-specific antibodies on the induction of specific cytotoxic T-cell and Th-cell responses in mice. The data show that VLP-specific antibodies did not measurably reduce antigen presentation in vitro or in vivo. Nevertheless, T-cell priming was slightly reduced by antigen-specific antibodies; however, the overall reduction was limited and vaccination with VLPs in the presence of VLP-specific antibodies still resulted in protective T-cell responses. Thus, carrier suppression is unlikely to be a limiting factor for VLP-based T-cell vaccines.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=538584Documentos Relacionados
- Radioresistance of Carrier-Specific Helper Thymus-Derived Lymphocytes in Mice
- Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
- Virus-Like Particles in Cephalosporium acremonium
- Requirements for Budding of Paramyxovirus Simian Virus 5 Virus-Like Particles
- Structural Requirements for the Assembly of Norwalk Virus-Like Particles