VITAMINA C PLASMÁTICA ESTÁ NEGATIVAMENTE ASSOCIADA COM A ATIVIDADE DAS AMINOTRANSFERASES EM PACIENTES COM HEPATITE C NÃO TRATADOS / PLASMATIC VITAMIN C IN NON-TREATED HEPATITIS C PATIENTS IS NEGATIVELY ASSOCIATED WITH AMINOTRANSFERASE ACTIVIES
AUTOR(ES)
Rosane Maria Souza dos Santos
DATA DE PUBLICAÇÃO
2007
RESUMO
In this study, the possible relationship between aminotransferase activities and markers of oxidative stress in hepatitis C patients was evaluated. Patients with HCV (hepatitis C virus) infection confirmed by positive HCV RNA in serum, without treatment to hepatitis C were divided into three groups: group I (15 to 39 U/L); group II (41 to 76 U/L); group III (81 to 311 U/L) of alanine aminotransferase (ALT) activity. A number of parameters were examined in blood as indicators of oxidative stress, including catalase, gluthatione peroxidase, thiobarbituric acid-reactive species (TBARS), non-protein thiol groups (NP-SH), protein thiol groups (P-SH) and vitamin C. The results demonstrated that markers of oxidative stress NP-SH, P-SH, TBARS, glutathione peroxidase and catalase activities measured in blood of these study groups were not significantly differents (P>0.05). The antioxidant vitamin C was significantly decreased in Group III (P=0.001) and Group II (P=0.03) when compared with Group I. The vitamin C level correlated negatively with AST activity (r=-0.29, P=0.042) for all patients. Our data suggested that vitamin C in plasma determination could be an additional indicator of hepatitis C severity, since plasma vitamin C was negatively associated with aminotransferase activities. Antioxidant therapy, such as vitamin C, may therefore have a role in retarded disease progression in liver
ASSUNTO(S)
vitamina c hepatite c bioquimica antioxidantes antioxidants aminotransferases aminotransferases hepatitis c oxidative stress estresse oxidativo vitamin c
ACESSO AO ARTIGO
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