Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
AUTOR(ES)
Scheja, Agneta
FONTE
BioMed Central
RESUMO
In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=30710Documentos Relacionados
- Raised concentrations of von Willebrand factor antigen in systemic sclerosis.
- Carbohydrate of the Factor VIII/von Willebrand Factor in von Willebrand's Disease
- Factor VIII/von Willebrand factor protein. Galactose a cryptic determinant of von Willebrand factor activity.
- Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis.
- Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC).