What brings pericytes to tumor vessels?

AUTOR(ES)

Jain, Rakesh K.

FONTE

American Society for Clinical Investigation

RESUMO

Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-β, expressed by pericytes, plays a central role in blood vessel maturation. A new study reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte interaction.

Documentos Relacionados

• Does unidirectional vesicular transport occur in retinal vessels?
• What makes blood vessels grow?
• Studies on developing retinal vessels. X. Formation of the basement membrane and differentiation of intramural pericytes.
• Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
• New president brings GP's perspective to CMA's top job