Xylitol inhibits J774A.1 macrophage adhesion in vitro

AUTOR(ES)

Ferreira, Aline Siqueira, Souza, Maria Aparecida de, Raposo, Nádia Rezende Barbosa, Ferreira, Ana Paula, Silva, Silvio Silvério da

FONTE

Brazilian Archives of Biology and Technology

DATA DE PUBLICAÇÃO

2011-12

RESUMO

The aim of this work was to evaluate the effect of xylitol on J774A.1 macrophage adhesion. Adhesion consisted of a three-hour interval, at room temperature, followed by washing and cell incubation at 37ºC/5% CO2/ 48h. Xylitol was used to treat the cells either before (for 24h) or after the cell incubation (for 48h) at 5% as final concentration in both the situations. It was found that xylitol was effective in preventing the adhesion in both the conditions in spite of the former being 100-fold greater and significant (p < 0.001). The results pointed to an important xylitol action on macrophage adhesion, which should be further investigated as an inflammatory control.

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