Yersinia pseudotuberculosis Produces a Cytotoxic Necrotizing Factor

AUTOR(ES)

Lockman, Hank A.

FONTE

American Society for Microbiology

RESUMO

Cell extracts from Yersinia pseudotuberculosis induced multinucleation in HEp-2 cells in a manner similar to the effect caused by Escherichia coli cytotoxic necrotizing factor (CNF). The activity was not dependent on the Yersinia 70-kb virulence plasmid, and the activity was not inhibited by antibodies capable of neutralizing E. coli CNF type 1. The nucleotide sequence of the Yersinia cnf gene was 65.1% identical to the E. coli cnf gene.

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