yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.
AUTOR(ES)
Semba, K
RESUMO
An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=386306Documentos Relacionados
- Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.
- The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.
- Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl.
- A distinctive family of embryonic protein-tyrosine kinase receptors.
- The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor.