Aryl Hydrocarbon Receptor Ahr
Mostrando 1-12 de 39 artigos, teses e dissertações.
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1. Effects of 1,25-dihydroxyvitamin D3 on experimental periodontitis and AhR/NF-κB/NLRP3 inflammasome pathway in a mouse model
Abstract Vitamin D has been known to have important regulatory functions in inflammation and immune response and shows inhibitory effects on experimental periodontitis in animal models. However, the potential mechanism has yet to be clarified. Recent studies have highlighted Aryl hydrocarbon receptor (AhR) and its downstream signaling as a crucial regulator
J. Appl. Oral Sci.. Publicado em: 04/11/2019
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2. Polymorphism of the aryl-hydrocarbon receptor gene in intron 10 of human cancers
Polychlorinated dibenzo-p-dioxins (PCDDs) and related halogenated aromatic hydrocarbons (e.g., PCDFs), often called "dioxins", are ubiquitously present environmental contaminants. Some of them, notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are among the most toxic synthetic compounds known. The biological effects of dioxins are mediated via the aryl hy
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-11
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3. Study the function of genes regulating the hypoxia state in determining the intensity inflammatory response. / Estudo da correlação entre a expressão de genes reguladores do estado de hipóxia e a intensidade da resposta inflamatória aguda.
Hypoxia occurs when the demand for molecular oxygen necessary to generate ATP is insufficient. Genes activated by hypoxia comprise the Hif-1a gene (Hypoxia-Inducible Factor 1a), Vegf-a (Vascular Endothelial Growth Factor a), Arnt and Vhl (von Hippel-Lindau). In this study we used lines of mice genetically selected for high (AIRmax) or low (AIRmin) acute infl
Publicado em: 2009
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4. Skin and lung carcinogenesis in mice Selected for acute inflammatory response (AIR). / Carcinogênese de pele e pulmão em linhagens de camundongos selecionados segundo a reatividade inflamatória aguda.
AIRmax mice are resistant and AIRmin susceptible to skin carcinogenesis by repeated DMBA doses. AIRmin mice developed initial contact hypersensitivity reaction (CHS) and late skin and lung tumors. The aryl hydrocarbon receptor (AHR) plays important roles in DMBA metabolism. Upon binding to agonist this transcription factor induces the expression of CYP P450
Publicado em: 2007
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5. Hematotoxicity for xenobiotics of the type polycyclic aromatic hydrocarbon in mice AIRmax and AIRmin. / Hematotoxicidade por xenobióticos do tipo hidrocarbonetos aromáticos em camundongos AIRmax e AIRmin.
Camundongos tratados com DMBA, hidrocarboneto policíclico aromático (HPA), diminuem células da medula óssea (MO) e baço. Este processo envolvido na metabolização dos HPA depende da ativação do receptor aryl hidrocarboneto (Ahr). Duas linhagens de camundongos selecionados geneticamente para máxima (AIRmax) ou mínima (AIRmin) resposta inflamatória
Publicado em: 2007
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6. A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors
The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice
The National Academy of Sciences.
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7. Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, until now described only in vertebrates, that mediates many of the carcinogenic and teratogenic effects of certain environmental pollutants. Here, we describe orthologs of AHR and its dimerization partner AHR nuclear translocator (ARNT) in the nematode Caenorhabditis elegans, enc
The National Academy of Sciences.
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8. G-protein signalling negatively regulates the stability of aryl hydrocarbon receptor
Aryl hydrocarbon receptor (AhR) is a transcription factor that works as a dioxin receptor and is also involved in various physiological phenomena, including development and cell proliferation. Here, we show that the Gα13 signal destabilizes AhR by promoting the ubiquitination of AhR. Gα13 interacts directly with AhR-interacting protein (AIP) and inhibits t
Nature Publishing Group.
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9. Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: expressionvectors with bi-directional promoters for use in Saccharomyces cerevisiae.
The pBEVY (bi-directional expression vectors for yeast) plasmids were designed with constitutive and galactose-induced bi-directional promoters to direct the expression of multiple proteins in Saccharomyces cerevisiae . Using human estrogen receptor as a test gene, relatively balanced expression levels from each side of a bi-directional promoter were observe
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10. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system
The aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity. Over 30 years of research has uncovered additional roles for the AHR in xenobiotic metabolism and normal vascular development. Activation of the AHR has long been known to cause immunotoxicity, including thymic involution. Recent data suggesting a role for the AHR
Blackwell Science Inc.
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11. Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione*
Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by aldo-keto reductases are ligands for the aryl hydrocarbon receptor (AhR) (Burczynski, M. E., and Penning, T. M. (2000) Cancer Res. 60, 908–915). They induce oxidative DNA lesions (reactive oxygen species-mediated DNA strand breaks and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dGuo) formation)
American Society for Biochemistry and Molecular Biology.
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12. Agonist and Chemopreventative Ligands Induce Differential Transcriptional Cofactor Recruitment by Aryl Hydrocarbon Receptor
Aryl hydrocarbon receptor (AHR) is a transcription factor whose activity is regulated by environmental agents, including several carcinogenic agonists. We measured recruitment of AHR and associated proteins to the human cytochrome P4501A1 gene promoter in vivo. Upon treatment with the agonist β-naphthoflavone, AHR is rapidly associated with the promoter and
American Society for Microbiology.