Arylpiperazines
Mostrando 1-2 de 2 artigos, teses e dissertações.
-
1. Molecular modeling of arylpiperazine compounds and their interactions with the 5-HT1A receptor / Modelagem molecular de compostos arilpiperazínicos e suas interações com o receptor 5-HT1A
Selective serotonin reuptake inhibitors (SSRIs) are the most important class of antidepressants in current clinical use. However, they present the serious drawback of a delay of two to six weeks in the onset of therapeutic effect. Clinical studies have shown that when a 5-HT1A receptor antagonist is administrated along with a SSRI, an increase of extracellul
Publicado em: 2008
-
2. Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in Escherichia coli Overexpressing RND Efflux Pumps
Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of le
American Society for Microbiology.