Assay Of Reduced Models
Mostrando 1-12 de 43 artigos, teses e dissertações.
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1. MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model
Abstract Purpose To investigate the role and related mechanisms of miR-106a in sepsis-induced AKI. Methods Serum from sepsis and healthy patients was collected, sepsis mouse model was established by cecal ligation and puncture (CLP). TCMK-1 cells were treated with lipopolysaccharide (LPS) and transfected with THBS2-small interfering RNA (siTHBS2), miR-10
Acta Cir. Bras.. Publicado em: 19/08/2019
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2. Production, characterization and toxicology assay of creatine pegylated nanoliposome with polysorbate 80 for brain delivery
ABSTRACT Creatine acts intracellularly as energy buffer and storage, demonstrating protective effects in animal models of neurodegenerative diseases. However, its permeability throught blood-brain barrier (BBB) is reduced. The aim of the present study was developing a carrier to facilitate the delivery of creatine to the central nervous system. Creatine nano
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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3. Anti-angiogenic effects of ethanolic extract of Artemisia sieberi compared to its active substance, artemisinin
Abstract Angiogenesis plays a key role in tumor growth, invasion and metastasis of cancer diseases and therefore, the inhibition of angiogenesis can provide an important therapeutic approach in cancer diseases. This study was designed to compare the anti-angiogenic activities of the ethanolic extract of Artemisia sieberi Besser, Asteraceae, and its active su
Rev. bras. farmacogn.. Publicado em: 2016-06
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4. Influence of supragingival biofilm control and smoking habit on Interleukin-1β concentration
This investigation compared gingival crevicular fluid (GCF) interleukin-1β (IL-1β) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 ± 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingi
Braz. oral res.. Publicado em: 2015
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5. Ethyl-p-methoxycinnamate isolated from kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions
OBJECTIVE: The present study aimed to investigate the mechanisms underlying the anti-inflammatory and anti-angiogenic effects of ethyl-p-methoxycinnamate isolated from Kaempferia galanga. METHODS: The anti-inflammatory effects of ethyl-p-methoxycinnamate were assessed using the cotton pellet granuloma assay in rats, whereby the levels of interleukin-1 and
Clinics. Publicado em: 2014-02
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6. Antioxidant effect of mogrosides against oxidative stress induced by palmitic acid in mouse insulinoma NIT-1 cells
Excessive oxidative stress in pancreatic β cells, caused by glucose and fatty acids, is associated with the pathogenesis of type 2 diabetes. Mogrosides have shown antioxidant and antidiabetic activities in animal models of diabetes, but the underlying mechanisms remain unclear. This study evaluated the antioxidant effect of mogrosides on insulinoma cells un
Braz J Med Biol Res. Publicado em: 18/11/2013
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7. Ação hepatoprotetora do antioxidante quercitina no modelo esperimental de esteato-hepatite não alcoólica
Introduction: Non-alcoholic steatohepatitis is a disease with a high incidence, difficult diagnosis, and yet no effective treatment. This reasons lead to the use of experimental models for induction of NASH, and the study of routes developing this disease, as well as attempts to a effective therapy. Aims: This study was designed to develop an experimental mo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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8. Atividade Antinociceptiva, em dores agudas, de um novo fator extraído da secreção cutânea de Rhinella jimi (Amphibia Anura) / Antinociceptive activity in acute pain, a new factor extracted from the skin secretion of Rhinella jimi (Amphibia - Anura)
Pain control has been an important focus of health for a long time. The ideal analgesic should be powerful, promoting maximum pain relief, but must submit a minimum adverse symptoms. The opioid agonists are used in treatment of intense acute pains and chronic pains in terminal patients, although they present important side effects, such as constipation, resp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/12/2009
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9. InvestigaÃÃo dos efeitos centrais e gastroprotetores do isopulegol em camundongos / Evaluation of the central nervous system and gastroprotective effects of isopulegol in mice.
Isopulegol is a monoterpene alcohol present in the essential oils of various plants, and has been used in the manufacture of fragrances with blossom compositions. In order to investigate its effects on animal models of CNS actions, isopulegol was administered to male Swiss mice at single doses of 25 and 50 mg/kg 30 (i.p.) or 60 min (p.o.) before the experime
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/08/2009
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10. Ventilação natural por efeito chaminé : estudo em modelo reduzido de pavilhões industriais / Natural ventilation for buoyancy - study of model reduced of industrial pavilions
A ventilação nas edificações tem por objetivo principal criar um ambiente interno confortável e saudável, preservando a qualidade do ar interior. Um dos principais sistemas de renovação do ar, e praticamente a única opção economicamente viável, utilizado no projeto de ambientes industriais é a ventilação natural. Esta pode ser promovida por do
Publicado em: 2009
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11. Investigation of adenosine endogenous increase decurrent of D-Frutose-1,6-difosfato administration, a glycolytic intermediate. / Investigação do aumento endógeno de adenosina decorrente da administração do intermediário glicolítico D-Frutose-1,6-difosfato
D-Fructose-1,6-bisphosphate (F1,6BP), a high-energy glycolytic pathway intermediate, is reported to have a many pharmacologically effect, but its underlying mechanism of action in inflammation is incompletely understood. In this study, the aim was to examine the function of F1,6BP on cytokines and adenosine. Then, the possible F1,6BP anti-inflammatory activi
Publicado em: 2009
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12. ATIVIDADE ANTINOCICEPTIVA DO ÁCIDO MIRSINÓICO B / ANTINOCICEPTIVE ACTIVITY OF MIRSINOIC B ACID
Mirsinoic B Acid (MBA) is a prenilate benzoic acid isolated from Rapanea sp. Various studies have shown that compounds of this type have antifungal, molluscicidal and antiparasitic activity. The objective of this study was to evaluate the role of MBA in the pain process, and the possible antinociceptive mechanisms involved, using some in vivo pharmacological
Publicado em: 2006