Association Discovery
Mostrando 1-12 de 114 artigos, teses e dissertações.
-
1. A carbamazepina é efetiva no tratamento da neuralgia do trigêmeo?
Sim. Carbamazepina e oxcarbazepina são drogas de primeira escolha no tratamento da neuralgia do trigêmeo e oferecem controle inicial significativo da dor em quase 90% dos pacientes. Possuem o mesmo mecanismo de ação, o bloqueio do canal de sódio voltagem-dependente de forma dependente da frequência, resultando na estabilização de membranas neurais
Núcleo de Telessaúde Santa Catarina. Publicado em: 12/06/2023
-
2. Discovery of Thiopyrimidinone Derivatives as a New Class of Human Aldose Reductase Inhibitors
Diabetes is a chronic metabolic disorder characterized by insufficient insulin production, the cells’ inability to use this insulin, or a combination of both, leading to secondary complications such as diabetic neuropathy and retinopathy. One way to prevent or control such complications is the use of aldose reductase (AR) inhibitors. In this work, we synth
Journal of the Brazilian Chemical Society. Publicado em: 2022
-
3. Organizing pneumonia in a patient with hodgkin's lymphoma and large B cell lymphoma: a rare association
ABSTRACT Toxoplasmosis is a zoonotic infection caused by the protozoan parasite Toxoplasma gondii. The infection is widely disseminated in the human population and is usually benign or asymptomatic. Systemic T. gondii infection presents risks for pregnant women and AIDS patients. Although rare, T. gondii can cause outbreaks in urban centers. The origin of th
Hematol., Transfus. Cell Ther.. Publicado em: 2020-06
-
4. Users’ satisfaction with the public dental service: the discovery of new patterns
Resumo Introdução Em relação à saúde bucal, pouco se avançou sobre como melhorar a qualidade no atendimento odontológico. Objetivo O objetivo deste estudo foi identificar fatores demográficos que afetam a satisfação de usuários do serviço público odontológico, sob a análise de uma metodologia estratégica e de alta consistência. Método A
Cad. saúde colet.. Publicado em: 27/06/2019
-
5. Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 years post-discovery
ABSTRACT The first description of patients with combined pituitary hormone deficiencies (CPHD) caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and genetic characteristics of patients with PROP1 mutations and summarized the phenotypes of 14 patients with 7 different pathogenic PROP1 mutations followed at the Hospital das Clínica
Arch. Endocrinol. Metab.. Publicado em: 13/05/2019
-
6. PCSK9 Inhibitors: Clinical Relevance, Molecular Mechanisms, and Safety in Clinical Practice
Resumo A doença arterial coronariana (DAC) é uma das principais causas de mortalidade. Níveis circulantes elevados de lipoproteína de baixa densidade (LDL) no sangue estão associados com mortalidade cardiovascular, seja por um papel etiológico ou por sua associação com a progressão da DAC em si. Estudos clínicos randomizados mostram que, quando os
Arq. Bras. Cardiol.. Publicado em: 28/02/2019
-
7. Synergistic antibacterial effect of statins with the complex {[1-(4-bromophenyl)-3-phenyltriazene N 3 -oxide-κ 2 N 1 ,O 4 ](dimethylbenzylamine-κ 2 C 1 ,N 4 )palladium(II)}
Abstract The treatment of infections caused by resistant microorganisms represents a big challenge in healthcare due to limited treatment options. For this reason, the discovery of new active substances which are able to perform innovative and selective actions is of great impact nowadays. Statins and triazenes (TZC) have consolidated as a promising class of
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
-
8. Genetics of osteoporosis: searching for candidate genes for bone fragility
ABSTRACT The pathogenesis of osteoporosis, a common disease with great morbidity and mortality, comprises environmental and genetic factors. As with other complex disorders, the genetic basis of osteoporosis has been difficult to identify. Nevertheless, several approaches have been undertaken in the past decades in order to identify candidate genes for bone
Arch. Endocrinol. Metab.. Publicado em: 2016-08
-
9. Antibacterial, antifungal and cytotoxic activities exhibited by endophytic fungi from the Brazilian marine red alga Bostrychia tenella (Ceramiales)
Abstract Marine environment is one of the most important sources regarding natural products research. Besides, marine microorganisms have been denominated as a talented natural source for discovery of new leads. Although the association of macroalgae and fungi has been described regarding ecological issues, there is a lack of studies about marine seaweed end
Rev. bras. farmacogn.. Publicado em: 2015-12
-
10. Influence of ?S-globin haplotypes and hydroxyurea on tumor necrosis factor-alpha levels in sickle cell anemia
Background: Sickle cell anemia is a chronic inflammatory disease characterized by an increased production of proinflammatory cytokines including tumor necrosis factor-alpha. Hydroxyurea, by decreasing the polymerization of hemoglobin, reduces inflammatory states. The effect of the genetic polymorphisms of sickle cell patients on tumor necrosis factor-alpha
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-04
-
11. DNA repair diseases: what do they tell us about cancer and aging?
The discovery of DNA repair defects in human syndromes, initially in xeroderma pigmentosum (XP) but later in many others, led to striking observations on the association of molecular defects and patients' clinical phenotypes. For example, patients with syndromes resulting from defective nucleotide excision repair (NER) or translesion synthesis (TLS) present
Genet. Mol. Biol.. Publicado em: 2014
-
12. Proposta de traduÃÃo dos princÃpios da coordenaÃÃo modular em parÃmetros aplicÃveis ao building information modeling. / Study for the translation of the modular coordination principles for the building information modeling parameters
Due to changes occurring in the Civil Construction scenario, it is important to emphasize the challenge to achieve the growing demand for housing and overcome deficiencies of the sector related to productivity and the reliability of the products, from design to construction. In this context, Modular Coordination and Building Information Modeling (BIM) emerge
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/04/2012