Asymmetric Allylation
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Sintese e atividade biologica de analogos furanicos da goniotalamina / Synthesis and biological activity of furan analogues of goniothalamin
This work describes the preparation of furan analogues of goniothalamin (compounds 31, 32 and 33) in both enantiomeric forms through the utilization of Keck asymmetric allylation and ring-closing methatesis reaction. These analogues were prepared in good overall yield and excellent enantiomeric ratio. These novel compounds were evaluated as antiproliferative
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/07/2009
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2. Alilação e crotilação catalítica e enantiosseletiva de aldeídos
The field of chiral catalysis has experienced explosive growth over the last two decades. By now, many of the classical reactions in organic synthesis can be carried out efficiently in asymmetric manner. As one of the fundamental and powerful C-C bond-forming reactions, enantioselective catalytic allylation (ECA) and crotylation (ECC) of aldehydes has attrac
Química Nova. Publicado em: 2006-10
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3. Goniotalamina, epoxigoniotalamina, argentilactona e derivados : sinteses totais e atividades antiproliferativas contra celulas tumorais humanas / Goniothalamin, goniothalamin oxide and argentilactone: total syntheses and antiproliferative activies against cells of human cancer
Natural goniothalamin (24), goniothalamin oxide (25) and argentilactone (23) are 5,6-di-hydro-2H-pyran-2-one that display many interesting biological activities. The total syntheses of these natural products as well as some of their derivatives are described. Goniothalamin (24) was synthesized via catalytic asymmetric allylation of a-benzyloxyacetaldehyde (3
Publicado em: 2005
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4. Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A
A highly convergent total synthesis of the potent anticancer agent (+)-phorboxazole A (1) is accomplished. Four components (3–6) are assembled with considerations for control of absolute and relative stereochemistry. Iterative asymmetric allylation methodology addresses key stereochemical features in the preparation of the 2,6-cis- and 2,6-trans-tetrahydro
National Academy of Sciences.