Axon Initial Segment
Mostrando 1-12 de 17 artigos, teses e dissertações.
-
1. Estudo da Expressão do Canal para Sódio Dependente de Voltagem Nav1.6 nas Células Octopus e Multipolares do PVCN no Núcleo Coclear do Sistema Auditivo
O presente trabalho teve como objetivo avaliar quais subunidades de canais para sódio voltagem dependentes estão presentes em subpopulações neuronais da região póstero-ventral do núcleo coclear (PVCN). Reações de imunofluorescência de simples ou dupla marcação em fatias parassagitais do núcleo coclear revelaram a expressão do canal Nav1.6 no se
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/10/2011
-
2. On re-excitation of feline motoneurones: its mechanism and consequences.
Conditions required for re-excitation of lumbosacral motoneurones, i.e. for double impulses in the motor axons associated with a single soma-dendritic action potential, were examined in cats anaesthetized with pentobarbitone and paralysed with gallamine triethiodide. Simultaneous recording from a motoneurone (intracellular, and in some experiments also extra
-
3. The transitional node of Ranvier at the junction of the central and peripheral nervous systems: an ultrastructural study of its development and mature form.
When the central-peripheral transitional node first appears it lies immediately distal to the astrocyte processes delineating the cord surface. Its initial location may be influenced indirectly by the astrocytes, since they determine the position of the transitional Schwann cell by preventing it from invading the central nervous system. The central end of th
-
4. Electrical inhibition of Purkinje cells in the cerebellum of the rat.
Monosynaptic activation of cerebellar Purkinje cells by a volley of parallel-fiber impulses is followed by a powerful disynaptic chemical inhibition mediated by molecular layer interneurons, including basket cells. Active zone established by basket preterminal axons on the body surface of the Purkinje cell account for this inhibition. However, morphological
-
5. Modeling back propagating action potential in weakly excitable dendrites of neocortical pyramidal cells.
Simultaneous recordings from the soma and apical dendrite of layer V neocortical pyramidal cells of young rats show that, for any location of current input, an evoked action potential (AP) always starts at the axon and then propagates actively, but decrementally, backward into the dendrites. This back-propagating AP is supported by a low density (-gNa = appr
-
6. A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia
In the primate cerebral cortex, morphologically and functionally diverse classes of local circuit neurons containing the inhibitory neurotransmitter γ-aminobutyric acid (GABA) differentially regulate the activity of pyramidal cells, the principal type of excitatory output neurons. In schizophrenia, GABA neurotransmission in the prefrontal cortex (PFC) appea
The National Academy of Sciences.
-
7. Comparison of antidromic and orthodromic action potentials of identified motor axons in the cat's brain stem.
Recordings were made from identified central axons at a known distance from their somata, to compare the action potentials resulting from antidromic and synaptic excitation. By taking advantage of the anatomical configuration within the brain stem of the motoneurones innervating the retractor bulbi muscle in the orbit, their axons were penetrated in the VIth
-
8. Action potential initiation and propagation in rat neocortical pyramidal neurons.
1. Initiation and propagation of action potentials evoked by extracellular synaptic stimulation was studied using simultaneous dual and triple patch pipette recordings from different locations on neocortical layer 5 pyramidal neurons in brain slices from 4-week-old rats (P26-30) at physiological temperatures. 2. Simultaneous cell-attached and whole-cell volt
-
9. Monoclonal antibodies to cerebellar pinceau terminals obtained after immunization with brain mRNA-injected Xenopus oocytes.
A method was developed to produce monoclonal antibodies to brain cell antigens by using Xenopus oocytes as immunological vectors. The method consists in injecting Xenopus oocytes with rat brain mRNA to express foreign proteins and using the oocytes for immunization. Immunizations were preceded by immunotolerization of mice to antigens of native oocyte membra
-
10. Functional distribution of three types of Na+ channel on soma and processes of dorsal horn neurones of rat spinal cord.
1. Voltage-gated Na+ channels and their distribution were studied by the patch-clamp technique in intact dorsal horn neurones in slices of newborn rat spinal cord and in neurones isolated from the slice by slow withdrawal of the recording pipette. This new method of neurone isolation was further used to study the roles of soma and axon in generation of actio
-
11. Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels*
Voltage-gated sodium channels (Nav) produce sodium currents that underlie the initiation and propagation of action potentials in nerve and muscle cells. Fibroblast growth factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Nav α subunit to modulate fast inactivation of the channel. In this study we solved the crystal structur
American Society for Biochemistry and Molecular Biology.
-
12. Autoradiographic localization of γ-aminobutyric acid receptors in the rat central nervous system by using [3H]muscimol
Muscimol, a structural analogue and potent agonist of γ-aminobutyric acid (GABA), was used in its tritiated form for the autoradiographic localization of GABA receptors in the rat central nervous system. [3H]Muscimol ([3H]M) was incubated with brain slices or was injected intracortically or into intraocular brain transplants. As indicated by [3H]M binding a