Behavioral Sensitization
Mostrando 1-12 de 54 artigos, teses e dissertações.
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1. Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats
The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactiv
Braz J Med Biol Res. Publicado em: 17/11/2017
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2. Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats
Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects of endogenous or exogenous estradiol and progesterone on cocaine-induced behavioral sensitization in 106 female rats. Ovariectomized female rats received progesterone (0.5 mg/mL), estradiol
Braz J Med Biol Res. Publicado em: 2014-06
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3. Brief daily postpartum separations from the litter alter dam response to psychostimulants and to stress
Neonatal handling induces several behavioral and neurochemical alterations in pups, including decreased responses to stress and reduced fear in new environments. However, there are few reports in the literature concerning the behavioral effects of this neonatal intervention on the dams during the postpartum period. Therefore, the aim of the current study was
Braz J Med Biol Res. Publicado em: 24/05/2013
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4. Effects of simultaneous exposure to stress and nicotine on nicotine-induced locomotor activation in adolescent and adult rats
Preclinical studies have shown that repeated stress experiences can result in an increase in the locomotor response to the subsequent administration of drugs of abuse, a phenomenon that has been termed behavioral cross-sensitization. Behavioral sensitization reflects neuroadaptive processes associated with drug addiction and drug-induced psychosis. Although
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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5. Effects of cocaine treatment in behavioral parameters and in the expression of CREB/pCREB and BDNF in adolescent and adult mice. / Efeitos do tratamento com cocaína sobre parâmetros comportamentais e na expressão de CREB/pCREB e BNDF em camundongos adolescentes e adultos.
The adolescence differs from adulthood in behavioral and neurochemichal aspects. Changes in the activity of the transcriptional factor CREB, neurotrofin BDNF and its receptor TrkB have been found in the mesolimbic-dopaminergic circuitry following the use of cocaine. This study evaluates the effects of cocaine administration in adolescent and adult mice in th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2011
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6. Efeitos da exposição ao etanol em camundongos adolescentes e adultos: comportamentos relacionados à recompensa, sensibilização comportamental e o papel dos sistemas dopaminérgico e glutamatérgico. / Effects of ethanol exposure in adolescent and adult mice: behaviors related to reward, behavioral sensitization and the role of the dopaminergic and glutamatergic systems.
O uso de drogas de abuso inicia-se principalmente na adolescência, um período em que o sistema nervoso central está passando por mudanças maturacionais neuroquímicas e neuroanatômicas. Assim, o objetivo desse projeto foi avaliar efeitos comportamentais e neuroquímicos da exposição ao etanol em camundongos adolescentes e adultos. O presente projeto i
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/09/2011
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7. O enriquecimento ambiental inibe a sensibilização comportamental ao etanol em camundongos: efeitos sobre o Egr-1 e a sinalização do BDNF. / Environmental enrichment blocks the behavioral sensitization to ethanol in mice: effects on Egr-1 and the BDNF signalling.
O uso de drogas de abuso pode levar a alterações neuroplásticas duradouras no encéfalo, entre elas a sensibilização comportamental (SC), um fenômeno relacionado à dependência. O enriquecimento ambiental (EA) permite estudar a influência do ambiente na resposta a diversas manipulações, entre elas o tratamento com drogas de abuso. O objetivo deste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2011
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8. Participação do sistema da orexina na sensibilização comportamental ao efeito estimulante do etanol em camundongos machos / Role of orexin system in ethanol-induced behavioral sensitization in male mice
Orexins are two neuropeptides, orexin-A and orexin-B, derived from the same precursor gene (pre-pro-orexin) produced by a few thousand neurons located in the perifornical area of the lateral hypothalamus. Despite having a restricted production, orexinergic neurons project widely to brain structures that regulate a number of endocrine and homeostatic function
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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9. Repeated exposure of adolescent rats to oral methylphenidate does not induce behavioral sensitization or cross-sensitization to nicotine
Several lines of evidence indicate that the use of stimulant drugs, including methylphenidate (MPD), increases tobacco smoking. This has raised concerns that MPD use during adolescence could facilitate nicotine abuse. Preclinical studies have shown that repeated treatment with an addictive drug produces sensitization to that drug and usually cross-sensitizat
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-07
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10. Potencial de abuso do modafinil e sensibilização cruzada com cocaína: um estudo pré-clínico. / Addictive potencial of modafinil and cross-sensitization with cocaine: a preclinical study.
Repeated or even a single exposure to all addictive drugs causes persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial controversy about the addictive potential
Publicado em: 2010
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11. Avaliação dos receptores 5-HT2C na expressão da sensibilização comportamental ao efeito estimulante do etanol. / Evaluation of 5-HT2C receptors on the expression of behavioral sensitization to the stimulant effect of ethanol
Não consta abstract.
Publicado em: 2010
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12. Fatores envolvidos no desenvolvimento e expressão da sensibilização comportamental ao efeito estimulante do modafinil e metanfetamina. / Factors involved in development and expression of modafinil and methamphetamine-induced behavioral sensitization.
A sensibilização comportamental refere-se ao aumento progressivo do efeito estimulante induzido após repetidas administrações de drogas de abuso como cocaína e anfetaminas. Estudos prévios sugerem que o ambiente pareado aos efeitos destas drogas parece ter um importante envolvimento no fenômeno da sensibilização comportamental. Além disso, o trata
Publicado em: 2010