Bezafibrate
Mostrando 1-12 de 23 artigos, teses e dissertações.
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1. Chemical degradation kinetics of fibrates: bezafibrate, ciprofibrate and fenofibrate
ABSTRACT Fibrates are drugs used for the treatment of hypertriglyceridemia and for the prevention of atherosclerosis. Three drugs in the fibrate class, ciprofibrate, fenofibrate and bezafibrate, were chosen for this study because their raw materials are readily available and because scientific publications on these compounds is limited. To evaluate their int
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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2. An increase in the cerebral infarction area during fatigue is mediated by il-6 through an induction of fibrinogen synthesis
OBJECTIVES:Our study aimed to investigate the impact of fatigue on the severity of stroke and to explore the underlying mechanisms.METHODS:Fatigued male rats underwent middle cerebral artery occlusion and the infarcted brain area was determined. Then, coagulation parameters were assessed in the fatigued group and a control group. In addition, the level of fi
Clinics. Publicado em: 2014-06
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3. BAFF promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis
Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology. A number of questions regarding its etiology are unclear. CD4+CD25+ regulatory T cells (Tregs) play a critical role in self-tolerance and, for unknown reasons, their relative number is reduced in PBC patients. B-cell-activating factor (BAFF)
Braz J Med Biol Res. Publicado em: 10/05/2013
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4. Nutritional and metabolic status of HIV-positive patients with lipodystrophy during one year of follow-up
OBJECTIVES: The aim of this prospective study was to compare changes in lipid metabolism and nutritional status after either 6 and 12 months of follow-up in subjects with lipodystrophy syndrome after traditional lifestyle therapy with or without fibric acid analogue intervention (bezafibrate and clofibrate). METHODS: Food intake, alterations in body composit
Clinics. Publicado em: 2011
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5. Agonistas PPAR (Rosiglitazona, Bezafibrato e Fenofibrato) e alterações bioquímicas e estruturais em órgãos-alvo de camundongos C57BL/6 alimentados com dieta hiperlipídica rica em sacarose / PPAR agonists (Rosiglitazone, Bezafibrate and Fenofibrate) and biochemical and structural changes in target organs of C57BL/6 mice fed a high-fat high-sucrose diet
This work aimed to evaluate the effect of peroxisome proliferator-activated receptor (PPAR) agonists (rosiglitazone, fenofibrate and bezafibrate) on lipid and glucose metabolism, body mass, and adipose and pancreatic tissue morphology in a model of diet-induced type 2 diabetes and overweight in mice. Two-month-old male C57BL/6 mice were fed a standard chow (
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/06/2010
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6. Caracterização de contaminantes presentes em sistemas de tratamento de esgotos, por cromatografia líquida acoplada à espectrometria de massas tandem em alta resolução
This work shows results on the characterization, by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-IT-TOF-MS) with electrospray ionization, of organic compounds present in raw and treated effluents from a combined sewage treatment systems (upflow anaerobic sludge blanket-trickling filter). The sewage samples were prepared by C1
Química Nova. Publicado em: 2010
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7. Effects of a methanolic fraction of soybean seeds on the transcriptional activity of peroxisome proliferator-activated receptors (PPAR)
Since the anti-inflammatory, antidiabetic and hypolipidemic effects of soy isoflavones may be mediated by activation of peroxisome proliferator-activated receptors (PPAR), the present study investigated whether the methanolic fractions obtained from soybean seeds (E1) and soybean seed coats with hypocotyls (E2) could influence PPARα, PPARγ and PPARβ/δ tr
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-06
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8. CARACTERIZAÇÃO, POR ESPECTROMETRIA DE MASSAS, DOS MICROPOLUENTES PRESENTES NO ESGOTO BRUTO E NOS EFLUENTES DE UM SISTEMA DE TRATAMENTO COMBINADO ANAERÓBIO-AERÓBIO
Pharmaceuticals and personal care products arrive at wastewater treatment plants after disposal, where arent completely degraded. There are only a few Brazilian studies which look for those organic micropolutants on the domestic sewage, as well as their removal in effluent treatment systems. This work developed an analytical methodology in order to identify
Publicado em: 2008
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9. Síntese e avaliação farmacológica de derivados fenóxi-acetoacetatos em receptores ativadados por proliferadores peroxissomais e em receptores de hormônio tireoideano
Nuclear receptors (NRs) are of great importance for the worldwide drug market since they are involved in mechanisms which influence several diseases that affect humanity like, for instance, diabetes mellitus (DM2), obesity, dislypemia and atherosclerosis. Peroxisome Proliferator-Activated Receptors (PPAR) and Thyroid Hormone Receptors (TR) control important
Publicado em: 2008
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10. BEZAFIBRATE: VALIDATION OF METHODOLOGY AND APPLICATION IN PHARMACOKINETIC STUDY OF PHARMACEUTICAL FORMULATIONS / BEZAFIBRATO: VALIDAÇÃO DE METODOLOGIA E APLICAÇÃO EM ESTUDO FARMACOCINÉTICO DE FORMULAÇÕES FARMACÊUTICAS
Os fibratos constituem uma importante classe de medicamentos utilizada no tratamento da dislipidemia, que é o principal fator de risco para o desenvolvimento de aterosclerose e incidência de doenças cardiovasculares. A presente dissertação aborda o desenvolvimento e a validação de procedimentos para análise de bezafibrato (BEZ) em produtos farmacêut
Publicado em: 2007
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11. Bezafibrate for the treatment of hypertriglyceridemia in HIV1-infected patients on highly active antiretroviral therapy
The use of highly active antiretroviral therapy (HAART) in HIV-infected patients has been associated with the development of risk factors for cardiovascular diseases (CD) including dyslipidemia and insulin resistance, hypertriglyceridemia being the most frequent metabolic disturbance in these patients. Fibrates are indicated when hypertriglyceridemia is acce
Brazilian Journal of Infectious Diseases. Publicado em: 2006-06
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12. Effect of bezafibrate on the sequelae of acute experimental focal cerebral ischaemia.
The possibility that the ability of bezafibrate to lower the oxygen affinity of haemoglobin might lead to an increased oxygen delivery to ischaemic cerebral tissue was explored in preliminary studies in two animal models. The combined morbidity and mortality of unilateral carotid ligation in the gerbil appeared to be reduced at two hours in bezafibrate treat