Biopharmaceutical
Mostrando 1-12 de 40 artigos, teses e dissertações.
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1. Structural and Functional Stabilization of Sericin from Bombyx mori Cocoons in a Biopolysaccharide Film: Bioorigami for Skin Regeneration
Development and optimization of a bioorigami film with silk sericin was pursued for skin regeneration. Several formulations were produced, with varying integrated sericin contents, viz. 0, 1, 2, 5, 10, 20 and 50 mgsericin mLfilm-1. The physico-chemical characteristics of the bioorigami films produced were evaluated via infrared spectrophotometry, X-ray diffr
J. Braz. Chem. Soc.. Publicado em: 2020-04
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2. The production of biopharmaceuticals in Brazil: current issues
Biopharmaceuticals are gaining a growing share of the pharmaceuticals market. In recent years, the Brazilian Health Surveillance Agency (ANVISA) has approved the registration of biological drugs with domestic production. Although Brazil is in the early stages of biopharmaceutical production, governmental incentives and the investment in private companies in
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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3. Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases
Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of c
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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4. Development of fast dissolving tablets of flurbiprofen by sublimation method and its in vitro evaluation
Flurbiprofen belongs to Biopharmaceutical Classification System (BCS) class II drugs which are poorly soluble in water. The objective of present research work was to prepare fast dissolving tablets of Flurbiprofen using varying concentrations of three different sublimating agents to improve the dissolution rate. Seven formulations were prepared containing di
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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5. Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of th
Matéria (Rio J.). Publicado em: 06/12/2018
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6. Antibacterial activity of 3,3',4'-Trihydroxyflavone from Justicia wynaadensis against diabetic wound and urinary tract infection
ABSTRACT The present investigation was designed to study the effect of an active compound isolated from Justicia wynaadensis against multi drug resistant organisms (MDRO's) associated with diabetic patients. The drug resistant pathogens implicated in wound and urinary tract infection of diabetic patients were isolated and identified by molecular sequencing.
Braz. J. Microbiol.. Publicado em: 2018-03
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7. The use of biosimilar medicines in oncology - position statement of the Brazilian Society of Clinical Oncology (SBOC)
A biosimilar is a biologic product that is similar to a reference biopharmaceutical product, the manufacturing process of which hinders the ability to identically replicate the structure of the original product, and therefore, it cannot be described as an absolute equivalent of the original medication. The currently available technology does not allow for an
Braz J Med Biol Res. Publicado em: 11/01/2018
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8. Heterologous fibrin sealant derived from snake venom: from bench to bedside – an overview
Abstract Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissu
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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9. Biopharmaceuticals from microorganisms: from production to purification
ABSTRACT The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN α, β, and γ) and growth hormones. The produ
Braz. J. Microbiol.. Publicado em: 2016-12
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10. Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders
The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-ima
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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11. TRIAGEM METABÓLICA POR PKS E NRPS EM ACTINOBACTÉRIAS ENDOFÍTICAS DE Citrus reticulata
Polyketides and non-ribosomal peptides are natural products widely found in bacteria, fungi and plants. The biological activities associated with these metabolites have attracted special attention in biopharmaceutical studies. Polyketide synthases act similarly to fatty acids synthetases and the whole multi-enzymatic set coordinating precursor and extending
Quím. Nova. Publicado em: 2015-03
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12. Applications of recombinant Pichia pastoris in the healthcare industry
Since the 1970s, the establishment and development of the biotech industry has improved exponentially, allowing the commercial production of biopharmaceutical proteins. Nowadays, new recombinant protein production is considered a multibillion-dollar market, in which about 25% of commercial pharmaceuticals are biopharmaceuticals. But to achieve a competitive
Braz. J. Microbiol.. Publicado em: 2013-12