Biotransformation Enzymes
Mostrando 1-12 de 50 artigos, teses e dissertações.
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1. Aspergillus niger: A Hundred Years of Contribution to the Natural Products Chemistry
Aspergillus niger is a phytopathogenic fungus responsible for the plant disease called “black mold”, and it is considered the most versatile microorganism for producing acids, proteins, and enzymes of industrial value, besides a variety of compounds of pharmacological interest. This review presents a century of contribution of A. niger in the natural pro
J. Braz. Chem. Soc.. Publicado em: 21/10/2019
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2. ENDOPHYTIC FUNGI FROM THE BRAZILIAN FLORA AND THEIR EMPLOYMENT IN BIOTRANSFORMATION REACTIONS
The biotransformation reactions are used as a successful alternative to derivatization by the traditional chemistry because they conduct to uncommon reactions, which would hardly be carried out by chemical synthesis. A wide diversity of compounds may be metabolized by fungi, leading to chemical derivatives through selective reactions that work under ecofrien
Quím. Nova. Publicado em: 26/08/2019
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3. Biotransformation of bromhexine by Cunninghamella elegans, C. echinulata and C. blakesleeana
Abstract Fungi is a well-known model used to study drug metabolism and its production in in vitro condition. We aim to screen the most efficient strain of Cunninghamella sp. among C. elegans, C. echinulata and C. blakesleeana for bromhexine metabolites production. We characterized the metabolites produced using various analytical tools and compared them with
Braz. J. Microbiol.. Publicado em: 2017-06
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4. Enzyme kinetic modelling and analytical solution of nonlinear rate equation in the transformation of D-methionine into L-methionine in batch reactor using the new homotopy perturbation method
A mathematical model of biotransformation of D-methionine into L-methionine in the cascade of the enzymes such as, D-amino acid oxidase (D-AAO), L-phenylalanine dehydrogenase (L-PheDH) and formate dehydrogenase (FDH) is discussed. The model is based on a system of coupled nonlinear reaction equations under non steady-state conditions for biochemical reaction
Quím. Nova. Publicado em: 2016-12
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5. Ligninolytic fungus Polyporus sp. S133 mediated metabolic degradation of fluorene
ABSTRACT This study aimed to investigate the impact of nonionic surfactants on the efficacy of fluorine degradation by Polyporus sp. S133 in a liquid culture. Fluorene was observed to be degraded in its entirety by Polyporus sp. S133 subsequent to a 23-day incubation period. The fastest cell growth rate was observed in the initial 7 days in the culture that
Braz. J. Microbiol.. Publicado em: 2016-09
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6. Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation
ABSTRACT The aim of this study was to characterize the mechanism of toxicity of fipronil on hepatocytes isolated from the rat and the effect of its biotransformation on the toxicological potential. The toxicity of fipronil was assessed by monitoring the oxygen consumption and mitochondrial membrane potential, intracellular ATP concentration, Ca2+ homeostasis
Braz. arch. biol. technol.. Publicado em: 2015-12
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7. Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid
ABSTRACTThe genus Erythrina, Fabaceae, is widely distributed in tropical and subtropical regions. Their flowers, fruits, seeds and bark are frequently used in folk medicine for its effects on the central nervous system such as anticonvulsant, antidepressant, analgesic, sedative, and hypnotic effects. Erythraline has been reported as one of the active compoun
Rev. bras. farmacogn.. Publicado em: 2015-10
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8. Endophytic fungi producing of esterases: evaluation in vitro of the enzymatic activity using pH indicator
A sensitive and efficient colorimetric method was optimized for detection of esterase enzymes produced by endophytic fungi for development of High-Throughput Screening (HTS). The fungi were isolated and obtained previously from plant species of Cerrado and Atlantic Forest located in areas of environmental preservation in the State of Sao Paulo / Brazil, as p
Braz. J. Microbiol.. Publicado em: 10/01/2014
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9. Fatos e tendências da biocatálise
Brazil is renowned for its biodiversity; however, its economy is based on exotic plants, extraction and unsustainable use of natural resources. This issue was addressed in a recent QN review entitled "Chemistry without Borders." In order to explore the potential of Brazilian biodiversity fully, sustainable development is required in key technological areas,
Quím. Nova. Publicado em: 2013
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10. Indução do sistema citocromo P450 em linhagens de hepatoma humano para utilização como modelo in vitro no desenvolvimento de fármacos / Induction of cytochrome P450 system in human hepatoma cell lines for using as in vitro model in drug development
In the early development stage of the new drugs, the pharmacological and toxicological properties are critical to define the potential use of the candidate drug. During this stage, several in vitro models systems are employed, including human hepatoma cell lines. However, the main limitation of the use of cell lines as in vitro model is the low expression le
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2012
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11. Aplicação de quitosana como suporte para a imobilização de enzimas de interesse industrial
Chitosan, poly[β-(1-4)-linked-2-amino-2-deoxy-D-glucose], is the N-deacetylated product of chitin which is a major component of arthropod and crustacean shells such as lobsters, crabs, shrimps, and cuttlefishes. In addition, chitosan has many significant biological and chemical properties such as biodegradability, biocompatibility and bioactivity as well as
Química Nova. Publicado em: 2011
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12. Prospecção de processos biotecnológicos de interesse industrial / Prospection of biotechnological processes of industrial interest
The objective of the present work was to study the biotransformation of monoterpenes to obtain natural flavor compounds (bioflavors), focusing the biochemical processes involved in the procedures investigated for possible industrial applications. Therefore, the study started with 70 strains, isolated in a previous study from a citrus processing plant and cap
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/09/2010