Biotransformation Metabolism
Mostrando 1-12 de 58 artigos, teses e dissertações.
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1. A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus
ABSTRACT The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6).
An. Acad. Bras. Ciênc.. Publicado em: 23/10/2017
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2. Biotransformation of bromhexine by Cunninghamella elegans, C. echinulata and C. blakesleeana
Abstract Fungi is a well-known model used to study drug metabolism and its production in in vitro condition. We aim to screen the most efficient strain of Cunninghamella sp. among C. elegans, C. echinulata and C. blakesleeana for bromhexine metabolites production. We characterized the metabolites produced using various analytical tools and compared them with
Braz. J. Microbiol.. Publicado em: 2017-06
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3. Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation
ABSTRACT The aim of this study was to characterize the mechanism of toxicity of fipronil on hepatocytes isolated from the rat and the effect of its biotransformation on the toxicological potential. The toxicity of fipronil was assessed by monitoring the oxygen consumption and mitochondrial membrane potential, intracellular ATP concentration, Ca2+ homeostasis
Braz. arch. biol. technol.. Publicado em: 2015-12
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4. Microsomal metabolism of erythraline: an anxiolitic spiroalkaloid
ABSTRACTThe genus Erythrina, Fabaceae, is widely distributed in tropical and subtropical regions. Their flowers, fruits, seeds and bark are frequently used in folk medicine for its effects on the central nervous system such as anticonvulsant, antidepressant, analgesic, sedative, and hypnotic effects. Erythraline has been reported as one of the active compoun
Rev. bras. farmacogn.. Publicado em: 2015-10
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5. Evaluation of microbiological and biomimetic models in stereoselective metabolism of risperidone by high-performance liquid chromatography / Avaliação de modelos microbiológicos e modelos biomiméticos no metabolismo estereosseletivo da risperidona por cromatografia líquida de alta eficiência
Risperidone is an atypical antipsychotic drug. Its metabolism yields in two hydroxylated chiral metabolites, 7-hydroxyrisperidone (7-RispOH) and 9-hydroxyrisperidone (9-RispOH). The 9-RispOH metabolite presents the same pharmacologic activity of the parent drug risperidone. This led this drug to be marketed as drug under the generic name paliperidone. Studie
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
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6. Investigação in vitro do efeito da restrição proteica no metabolismo do albendazol em ratos e estudos de inibição do crescimento de células tumorais humanas pelos enantiômeros do albendazol sulfóxido / Investigation in vitro of effect of protein restrict in the metabolism of albendazole in rats and growth inhibition studies in human tumor cells by enantiomers of albendazole sulphoxide
This work presents an in vitro investigation of protein restriction in the metabolism of albendazole (ABZ). The study was conducted with microsomal fractions obtained from Wistar rats using a High Performance Multidimensional Liquid Chromatography method which was developed and fully validated for the determination of the ABZ metabolites albendazole sulphoxi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/12/2011
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7. Avaliação da microalga marinha Lingulodinium polyedrum exposta ao fenol: biotransformação e atividade antioxidante / Evaluation of marine microalgae Lingulodinium polyedrum exposed to phenol: biotransformation and antioxidant activity
Devido à necessidade de se conhecer os impactos que as diversas atividades antropogênicas exercem sobre os ecossistemas torna-se relevante o estudo dos organismos aquáticos perante os resíduos tóxicos resultantes, com o objetivo de facilitar a identificação de áreas poluiídas ou contaminadas e estudos de meios atingidos por estes agentes poluentes.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2011
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8. Thymol and carvacrol: biotransformation and antifungal activity against the plant pathogenic fungi Colletotrichum acutatum and Botryodiplodia theobromae
Fungal growth in fruits may cause spoilage and result in a reduction of their quality and quantity. The aim of the current study was to investigate the antifungal activity and the metabolism of thymol and carvacrol by Colletotrichum acutatum and Botryodiplodia theobromae. The results showed that both compounds provided relatively good control against these p
Tropical Plant Pathology. Publicado em: 2011-02
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9. Planejamento, síntese, biotransformação e avaliação farmacológica de novos candidatos a protótipos de fármacos antipsicóticos / Planning, synthesis, biotransformation and pharmacological evaluation of new candidate prototype antipsychotic drugs
In the scope of a research program that aim the design, synthesis and pharmacological evaluation of new lead-compounds, we will describe in this work the design of new N-phenylpiperazines derivatives originally designed from clozapine (27) and LASSBio 579 (40) that shows antagonist profile in dopaminergic receptors. The compound 1-(4-nitrophenyl)-4-((1-pheny
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2010
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10. Avaliação do perfil metabólico da estavudina através do emprego da bioconversão e da modelagem molecular do citocromo P-450 CYP3A4 / Evaluation of the metabolic profile of stavudine through the use of bioconversion and molecular modeling of cytochrome P-450 CYP3A4
Before the approval of an active compound, metabolism studies are necessary to ensure its safety, once active metabolites could be synthesized during human biotransformation. The use of eukaryotic microorganisms for the study of drug metabolism has been widely explored, due to its capability of producing metabolites similar to the mammalians, and in silico s
Publicado em: 2009
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11. Efeitos da hidroquinona sobre atividades funcionais da célula endotelial e de neutrófilos / Effect of hydroquinone in the functional activity of endothelial cells and neutrophils
Hydroquinone (HQ) is a fenolic compound obtained after benzene metabolism, it is a component of cigarette, medicines, photographic developer, and it is also finding in some foods and medicinal herbs. Our research group has been shown that rats in vivo exposed to HQ present impaired leukocyte migration into lung during allergic or non-specific inflammation. I
Publicado em: 2009
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12. Modulação da atividade das enzimas de biotransformação de xenobióticos na malária murina letal e não-letal. / Modulation of the activity of enzymes of biotransformation of xenobiotics in the lethal and not-lethal murina malaria.
Durante as últimas três décadas, um expressivo número de estudos experimentais e clínicos mostrou que várias infecções e inflamações assépticas modulam a expressão e a atividade de enzimas citocromo P450 (CYP). Nesta linha de investigação, alguns estudos sugeriram que as atividades de CYP e a cinética de xenobióticos são alteradas também na
Publicado em: 2008