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Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Entendendo e interpretando os parâmetros utilizados por BLAST.
O método BLAST para determinação de similaridades entre sequências biológicas. Score e matrizes de substituição. Determinação de matrizes de substituição BLOSUM. Determinação de matrizes de substituição PAM. Resultados da teoria Estatística de comparação local de sequências. O Algoritmo usado por BLAST. NCBI-BLAST. Exemplo de busca.
Campinas: Embrapa Informática Agropecuária. Publicado em: 2011
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2. BLOOM BLAST Object Oriented Management: uma solução integrada para gerenciamento dos resultados do BLAST por meio de um paradigma orientado a objetos
Considered a special subject since the beginning of the 80s, bioinformatics can be defined as a way that covers all aspects of acquisition, processing, storage, distribution, analysis and interpretation of biological information. All this happens in a narrow sinergy with the molecular biology fundamental paradigm, which postulates that the genetic informatio
Publicado em: 2003
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3. Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base.
We describe a strategy for quickly identifying and positionally mapping human homologs of yeast genes to cross-reference the biological and genetic information known about yeast genes to mammalian chromosomal maps. Optimized computer search methods have been developed to scan the rapidly expanding expressed sequence tag (EST) data base to find human open rea
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4. RevTrans: multiple alignment of coding DNA from aligned amino acid sequences
The simple fact that proteins are built from 20 amino acids while DNA only contains four different bases, means that the ‘signal-to-noise ratio’ in protein sequence alignments is much better than in alignments of DNA. Besides this information-theoretical advantage, protein alignments also benefit from the information that is implicit in empirical substit
Oxford University Press.
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5. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
The organic cation transporter, OCT1, is a major hepatic transporter that mediates the uptake of many organic cations from the blood into the liver where the compounds may be metabolized or secreted into the bile. Because OCT1 interacts with a variety of structurally diverse organic cations, including clinically used drugs as well as toxic substances (e.g.,
The National Academy of Sciences.
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6. Panning for Genes—A Visual Strategy for Identifying Novel Gene Orthologs and Paralogs
We have developed a rapid visual method for identifying novel members of gene families. Starting with an evolutionary tree, 20–50 protein query sequences for a gene family are selected from different branches of the tree. These query sequences are used to search the GenBank and expressed sequence tag (EST) DNA databases and their nightly updates using the
Cold Spring Harbor Laboratory Press.
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7. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints
Membrane transporters maintain cellular and organismal homeostasis by importing nutrients and exporting toxic compounds. Transporters also play a crucial role in drug response, serving as drug targets and setting drug levels. As part of a pharmacogenetics project, we screened exons and flanking intronic regions for variation in a set of 24 membrane transport
The National Academy of Sciences.