Bone Marrow Chimeras
Mostrando 1-12 de 83 artigos, teses e dissertações.
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1. Estudo do modelo de quimeras de medula óssea (WT/IFNgR-KO) para examinar o papel do IFN-g sobre as células não leucocitárias na infecção pelo Trypanosoma cruzi. / Analysis of the model of bone marrow chimeras (WT/IFNg-R-KO) to examine the role of IFNK-g upon non leukocytes in Trypanosoma cruzi infection.
Although we know the role played by leukocytes in Trypanosoma cruzi control, we ignore the contribution of structural cells (myocytes, hepatocytes, etc). These cells could signal the presence of the parasite and/or mediate an effector activity which could increase in response to cytokines, as IFN-g. To evaluate if non-leukocytes respond to IFNg, contributing
Publicado em: 2008
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2. Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.
We previously have demonstrated that in radiation-induced bone marrow chimeras, T-cell self-Ia restriction specificity appeared to correlate with the phenotype of the bone marrow-derived antigen-presenting (or dendritic) cell in the thymus during T-cell development. However, these correlations were necessarily indirect because of the difficulty in assaying t
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3. Resistance to infection with Eimeria vermiformis in mouse radiation chimeras is determined by donor bone-marrow cells.
The course of infection with Eimeria vermiformis was determined in BALB/b, BALB/c, and C57BL/10ScSn (B10) mice and in radiation chimeras prepared from the H-2-compatible BALB/b and B10 mice. The BALB strains, irrespective of H-2 haplotype, were resistant, the B10 mice were susceptible, and in the chimeras infection was characterized by the genotype of the do
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4. Enhanced antibody affinity in sublethally irradiated mice and bone marrow chimeras.
Sublethally irradiated mice primed with dinitrophenyl (Dnp)-keyhole limpet hemocyanin immediately after irradiation or 30 days later and subsequently boosted with a second injection of antigen displayed a secondary response to Dnp characterized by antibody affinity greater than that in unirradiated controls. Also, in radiation chimeras primed with Dnp-keyhol
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5. Susceptibility of radiation chimeras to Trypanosoma cruzi.
Reciprocal bone marrow transfers were performed with C3H/HeJ mice, which are susceptible to infection with the Brazil strain of Trypanosoma cruzi, and resistant F1 (C3H/HeJ X C57BL/6J) mice. Mice reconstituted after lethal irradiation with syngeneic bone marrow displayed the resistance phenotype of the strain used, but neither C3H mice reconstituted with F1
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6. Hematopoietic microenvironment. Origin, lineage, and transplantability of the stromal cells in long-term bone marrow cultures from chimeric mice.
Studies of bone marrow transplant patients have suggested that the stromal cells of the in vitro hematopoietic microenvironment are transplantable into conditioned recipients. Moreover, in patients with myeloproliferative disorders, all of the stromal cells, which include presumptive endothelial cells, appear to be derived from hematopoietic precursors. To c
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7. Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin.
The fungal metabolite gliotoxin at low concentrations prevents mitogen stimulation of mature lymphocytes as a result of gliotoxin-induced genomic DNA degradation. Bone marrow, on the other hand, contains a subpopulation of cells resistant to gliotoxin at similar concentrations. This population includes the hemopoietic progenitor cells that grow in vitro in r
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8. CD8 T-cell recognition of macrophages and hepatocytes results in immunity to Listeria monocytogenes.
CD8 T cells are effective mediators of specific immunity to infection by Listeria monocytogenes, a bacterial pathogen that initially infects macrophages in the spleen and liver and subsequently spreads to hepatocytes and unidentified parenchymal cells in the spleen. To identify the in vivo target cells of L. monocytogenes-immune CD8 T cells, adoptive transfe
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9. Origin of hemopoietic stem cells in the embryonic bursa of Fabricius and bone marrow studied through interspecific chimeras
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10. Marrow transplantation from tolerant donors to treat and prevent autoimmune diseases in BXSB mice.
Autoimmune-prone BXSB male mice were supralethally irradiated and transplanted with CBA/H bone marrow cells. A complete and long-term chimerism was established when donor mice had been induced to develop tolerance of BXSB male antigens by combined treatment with BXSB male spleen cells and cyclophosphamide. Such chimeras did not express autoimmune phenomena o
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11. H-2-incompatible bone marrow chimeras produce donor-H-2-restricted Ly-2 suppressor T-cell factor(s).
To study adaptive-differentiation phenomena of T lymphocytes, suppressor T-cell factors (TsF) produced by Ly-2+ splenic T cells from fully allogeneic mouse bone marrow chimeras were analyzed. AKR mice irradiated and reconstituted with B10 marrow cells (B10----AKR chimeras) produced an Ly-2+ TsF after hyperimmunization with sheep erythrocytes. The TsF suppres
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12. Bone Marrow Chimeras Reveal Non-H-2 Hematopoietic Control of Susceptibility to Theiler's Virus Persistent Infection
The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The respective roles of hematopoietic and nonhe
American Society for Microbiology.