Bone Marrow Derived Macrophages Bmdms
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Estudo da interação da metaloprotease BmooMPα-I, isolada da peçonha de Bothrops moojeni (HOGE, 1965; Viperidae),com a citocina pró-inflamatória TNF-α.
A inflamação é um processo essencial para manutenção da homeostase, envolvendo eventos vasculares, migração e ativação de leucócitos. No entanto, suas manifestações exacerbadas, geralmente mediadas pelo aumento do nível de citocinas pró-inflamatórias como o fator de necrose tumoral (TNF-α), podem resultar em doenças crônicas, como artri
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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2. Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages
Detection of LPS in tissues is an integral component of innate immunity that acts to protect against invasion by Gram-negative bacteria. Plasma down-regulates LPS-induced cytokine production from macrophages, thereby limiting systemic inflammation in blood and distant tissues. To identify the protein(s) involved in this process, we used classical biochemical
The Society for Leukocyte Biology.
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3. Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects
Protective/suppressive major histocompatibility complex (MHC) class II alleles have been identified in humans and mice where they exert a disease-protective and immunosuppressive effect. Various modes of action have been proposed, among them differential expression of MHC class II genes in different types of antigen-presenting cells impacting on the T helper
The National Academy of Sciences.
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4. DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA
CpG-DNA and its related synthetic CpG oligodeoxynucleotides (CpG-ODNs) play an important role in immune cell survival. It has been suggested that Akt is one of the CpG-DNA-responsive serine/threonine kinases; however, the target protein of CpG-DNA that leads to Akt activation has not been elucidated. Here, we report that ex vivo stimulation of bone marrow-de
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5. ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability†
NF-κB1 p105 forms a high-affinity, stoichiometric interaction with TPL-2, a MEK kinase essential for TLR4 activation of the ERK mitogen-activated protein kinase cascade in lipopolysaccharide (LPS)-stimulated macrophages. Interaction with p105 is required to maintain TPL-2 metabolic stability and also negatively regulates TPL-2 MEK kinase activity. Here, aff
American Society for Microbiology.