Bone Marrow Stroma
Mostrando 1-12 de 63 artigos, teses e dissertações.
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1. The significance of the amoebocyte-producing organ in Biomphalaria glabrata
In molluscs, internal defence against microorganisms is performed by a single cell type, i.e., the haemocyte or amoebocyte. The origin of these cells in Biomphalaria glabrata was initially thought to be localised within the vasculo-connective tissue. More recently, origin from a single organ, termed the amoebocyte-producing organ (APO), has been postulated b
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-08
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2. Assessment of fibrosis and vascularization of bone marrow stroma of chronic myeloid Leukemia patients treated with imatinib mesylate and their relationship with the cytogenetic response
A Leucemia Mielóide Crônica (LMC) é uma doença mieloproliferativa caracterizada pela presença do cromossomo Filadélfia (translocação entre os cromossomos 9 e 22), que resulta na formação da proteína híbrida BCR-ABL. Atualmente o tratamento de pacientes com LMC é realizado com mesilato de imatinibe (MI), o qual promove a eliminação das células
Brazilian Journal of Pharmaceutical Sciences. Publicado em: 2011-06
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3. Establishment of an adherent cell layer from human umbilical cord blood
In addition to bone marrow and peripheral blood, stem cells also occur in human umbilical cord blood (HUCB), and there is an increasing interest in the use of this material as an alternative source for bone marrow transplantation and gene therapy. In vitro hematopoiesis has been maintained for up to 16 weeks in HUCB cultures, but the establishment of an adhe
Publicado em: 2010
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4. Atividade imunomoduladora da alga Chlorella vulgaris em camundongos portadores de tumos ascitico de Ehrlich / Immunolmodulatory activity of the alga Chlorella vulgaris in Ehrlich ascites tumor bearing mice
Chlorella vulgaris (CV) is a microscopic alga rich in nutrients. Besides the high nutritive value, this alga has shown important therapeutic properties. Many studies from our laboratory and others have shown the protective effects of CV against viral and bacterial infections, tumors, among others. In this work we evaluated the effects of the prophylactic/the
Publicado em: 2008
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5. Bone marrow stroma modulates the expression of several drug resistance/sensitivity genes in pediatric acute limphoblastic leukemia / O estroma da medula ossea e a sua influencia na expressão de genes de resistencia e sensibilidade a quimioterapicos na leucemia linfoide aguda (LLA) pediatrica
The intrinsic or acquired chemotherapy resistance composites one of the most important causes of failures in the treatment of pediatric ALL. The ALL and bone marrow microenvironment nteraction contributes for the proliferation and resistance to the chemotherapy regimen of leukemic cells probably through a great variety of cellular mechanisms, including incre
Publicado em: 2007
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6. Análise do transcriptoma durante a ontogenia do timo. / Analysis of the transcriptoma during the antogenia of the thymus.
The thymus is a complex organ structured by a stroma, which is formed mainly by cortical epithelial cells (cTECs) and medullary epithelial cells (mTECs) besides of other cell types such as dendritic cells (DC), macrophages, B lymphocytes and fibroblasts. Moreover, the T cell precursors arising from the bone marrow reach the thymus (thymocytes) maturing in T
Publicado em: 2007
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7. Dipeptidyl peptidase IV (CD26) activity in the hematopoietic system: differences between the membrane-anchored and the released enzyme activity
Dipeptidyl peptidase IV (DPP-IV; CD26) (EC 3.4.14.5) is a membrane-anchored ectoenzyme with N-terminal exopeptidase activity that preferentially cleaves X-Pro-dipeptides. It can also be spontaneously released to act in the extracellular environment or associated with the extracellular matrix. Many hematopoietic cytokines and chemokines contain DPP-IV-suscept
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-05
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8. Biology and clinical utilization of mesenchymal progenitor cells
Within the complex cellular arrangement found in the bone marrow stroma there exists a subset of nonhematopoietic cells referred to as mesenchymal progenitor cells (MPC). These cells can be expanded ex vivo and induced, either in vitro or in vivo, to terminally differentiate into at least seven types of cells: osteocytes, chondrocytes, adipocytes, tenocytes,
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-08
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9. Rescue of myeloid lineage-committed preprogenitor cells from cytomegalovirus-infected bone marrow stroma.
The effect of murine cytomegalovirus on myelopoiesis was studied in long-term bone marrow culture to find an in vitro correlate for the lethal virus interference with bone marrow reconstitution (W. Mutter, M. J. Reddehase, F. W. Busch, H.-J. Bühring, and U. H. Koszinowski, J. Exp. Med. 167:1645-1658, 1988). The in vitro generation of granulocyte-monocyte pr
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10. Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation.
In long-term bone marrow cultures, stroma-adherent progenitors proliferate significantly less than nonadherent progenitors. Thus, close progenitor-stroma interactions may serve to regulate or restrict rather than promote hematopoietic progenitor proliferation. We hypothesized that signaling through adhesion receptors on hematopoietic cells may contribute to
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11. What is marrow fibrosis after treatment of neuroblastoma?
AIMS: To test the hypothesis that the abnormal fibrous stroma of bone marrow found after treatment of disseminated neuroblastoma represents traumatic scarring. METHODS: Twenty six restaging bone marrow biopsy specimens from 14 children with disseminated neuroblastoma were compared with 37 from 37 children with acute lymphoblastic leukaemia. They were assesse
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12. Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function.
Treatment of chronic myelogenous leukemia (CML) with interferon-alpha frequently results in normalization of peripheral blood counts and, in up to 20% of patients, reestablishment of normal hematopoiesis. We hypothesize that interferon-alpha may restore normal adhesive interactions between CML progenitors and the bone marrow microenvironment and restore norm