Bothrops Asper Venom
Mostrando 1-12 de 13 artigos, teses e dissertações.
-
1. Development of a sensitive enzyme immunoassay (ELISA) for specific identification of Lachesis acrochorda venom
The snake genus Lachesis provokes 2 to 3% of snakebites in Colombia every year. Two Lachesis species, L. acrochorda and L. muta, share habitats with snakes from another genus, namely Bothrops asper and B. atrox. Lachesis venom causes systemic and local effects such as swelling, hemorrhaging, myonecrosis, hemostatic disorders and nephrotoxic symptoms similar
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
-
2. Ethnobotanic study of Randia aculeata (Rubiaceae) in Jamapa, Veracruz, Mexico, and its anti-snake venom effects on mouse tissue
In Mexico, medicinal plants are widely used. The use of Randia aculeata by healers against snakebites has never been scientifically tested in relation to possible effects on blood parameters and muscle tissue damage. Interviews were carried out in Jamapa, Veracuz, Mexico, with local residents to collect information about the traditional use of Randia aculeat
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 2012
-
3. Correlation of the inhibitory activity of phospholipase A2 snake venom and the antioxidant activity of Colombian plant extracts
Veneno de cobra continua a ser um problema importante de saúde em muitos países da América Latina. Apesar dos avanços na terapia antiveneno, os efeitos locais causados por fosfolipases A2 miotóxica (PLA2) presentes no veneno, ainda persistem. Em busca de alternativas para antagonizar a atividade da PLA2 do veneno de Bothrops asper, foram selecionados 36
Revista Brasileira de Farmacognosia. Publicado em: 29/10/2010
-
4. Functional and structural characterization of phospholipases A² isolated from Bothrops asper snake venom in Panamá
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
-
5. Functional and structural characterization of phospholipases A2 isolated of Bothrops asper snake venom from Panamá. / Caracterização funcional e estrutural de fosfolipases A2 isoladas da peçonha da serpente Bothrops asper do Panamá
Os envenenamentos causados pelas serpentes do gênero Bothrops são os mais importantes do ponto de vista médico e econômico na América Central. Dentre estas, a serpente Bothrops asper é responsável por 90% dos envenenamentos ofídicos registrados no Panamá anualmente. Apesar da relevância médica e econômica, só a peçonha de populações de B. asp
Publicado em: 2009
-
6. Estudos da inflamação e dor articulares em ratos e dos mecanismos da produção de TNF-a por macrófagos isolados, induzidos pela BaP1, uma metaloproteínase isolada do veneno da serpente Bothrops asper. / Studies on both rat articular inflammation and pain, and mechanisms involved in production of TNF-a by isolated macrophages induced by BaP1, a metalloproteinase isolated from Bothrops asper snake venom.
Metalloproteinases are major enzymes in snake venoms showing high grade of homology with mammal matrix metalloproteinases, present in high levels in inflamed joints. In this study we examined the ability of BaP1, to induce: i) inflammation and hypernociception in rat articular joints and participation of TNF-a and PGE2 in these effects, a
Publicado em: 2008
-
7. Isolation and characterization of a serine proteinase with thrombin-like activity from the venom of the snake Bothrops asper
A serine proteinase with thrombin-like activity was isolated from the venom of the Central American pit viper Bothrops asper. Isolation was performed by a combination of affinity chromatography on aminobenzamidine-Sepharose and ion-exchange chromatography on DEAE-Sepharose. The enzyme accounts for approximately 0.13% of the venom dry weight and has a molecul
Brazilian Journal of Medical and Biological Research. Publicado em: 17/12/2007
-
8. Neutralization of the edema-forming, defibrinating and coagulant effects of Bothrops asper venom by extracts of plants used by healers in Colombia
We determined the neutralizing activity of 12 ethanolic extracts of plants against the edema-forming, defibrinating and coagulant effects of Bothrops asper venom in Swiss Webster mice. The material used consisted of the leaves and branches of Bixa orellana (Bixaceae), Ficus nymphaeifolia (Moraceae), Struthanthus orbicularis (Loranthaceae) and Gonzalagunia pa
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-07
-
9. Efeito nociceptivo induzido por fosfolipases A2 (FLA2 variantes Lys49 e Asp49) isoladas do veneno de serpentes Bothrops asper: caracterização dos mecanismos centrais e determinantes moleculares / Nociceptive effect induced by phospholipase A2 (PLA2-Lys49 and PLA2-Asp49) isolated from Bothrops asper venom: characterization of central mechanisms and molecular determinants.
Fosfolipases A2 miotóxicas (Lys49, enzimaticamente inativa, e Asp49, com atividade) isoladas do veneno de Bothrops asper, induzem hipernocicepção. Assim, avaliamos os mecanismos estruturais, moleculares e mediadores centrais envolvidos neste efeito. A injeção intraplantar das FLA2s acarretou hiperalgesia, enquanto que apenas a FLA2-Asp49 induziu alodini
Publicado em: 2004
-
10. Purification and partial characterization of phospholipases A2 from Bothrops asper (barba amarilla) snake venom from Chiriguaná (Cesar, Colombia)
Components with phospholipase A2 activity were isolated by gel filtration and cationic exchange chromatography from the venom of Bothrops asper snakes from Chiriguaná, Colombia (9°22´N; 73°37´W). Five fractions were obtained by the gel filtration, and PLA2 activity was found in fraction 3 (F3). In the cationic exchange chromatography, F3 showed eight co
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2004
-
11. Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms
Neutralization of hyperalgesia induced by Bothrops jararaca and B. asper venoms was studied in rats using bothropic antivenom produced at Instituto Butantan (AVIB, 1 ml neutralizes 5 mg B. jararaca venom) and polyvalent antivenom produced at Instituto Clodomiro Picado (AVCP, 1 ml neutralizes 2.5 mg B. aspar venom). The intraplantar injection of B. jararaca a
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-10
-
12. Mediação química da hiperagesia induzida pelos venenos de serpentes Bothrops jararaca e Bothrops asper e por uma miotoxina com atividade de fosfolipase A2 isolada do veneno de Bothrops asper / Chemical mediation of hyperalgesia induced by Bothrops jararaca and Bothrops asper snake venoms and by a phospholipase A2 miotoxin isolated from Bothrops asper venom.
Bothrops venoms cause pronounced local tissue-damage characterized by hemorrhage, myonecrosis, edema and pain. Venom-induced pain has been poorly investigated, despite its clinical relevance. Furthermore, the ability of antivenom to neutralize hyperalgesia induced by these venoms is not known. In the present study the hyperalgesia and edema induced by Bothro
Publicado em: 2000