Bothrops Jararacussu
Mostrando 1-12 de 83 artigos, teses e dissertações.
-
1. O laser de baixa potência seria terapêutico para lesões causadas por acidentes ofídicos do gênero Bothrops?
Ainda não há evidências científicas em humanos, entretanto, em caráter experimental e de pesquisa, a laserterapia tem sido usada em lesões necróticas incapacitantes secundárias à picada por serpente na região amazônica, devido seu importante impacto em saúde pública pela retirada precoce do trabalhador na geração de renda. Assim, os benefí
Núcleo de Telessaúde Amazonas. Publicado em: 12/06/2023
-
2. Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes
This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of their ability to inhibit some in vitro (coagulant, proteolytic and hemolytic) and in vivo (hemorrhagic, edematogenic and lethality) toxic activities of Bothrops jararaca and Bothrops jararacussu venoms. Compounds have been synthesized from the coupling of intermedi
Journal of the Brazilian Chemical Society. Publicado em: 2022
-
3. BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation
ABSTRACT Background: Breast cancer is the neoplasm with both the highest incidence and mortality rate among women worldwide. Given the known snake venom cytotoxicity towards several tumor types, we evaluated the effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, and MDAMB231 breast cancer cell lines. Methods: BthTX-I cytotoxicity was determined
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/07/2019
-
4. Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases
Abstract Background: L-amino acid oxidases isolated from snake venoms (SV-LAAOs) are enzymes that have great therapeutic potential and are currently being investigated as tools for developing new strategies to treat various diseases, including cancer and bacterial infections. The main objective of this study was to make a brief evaluation of the enzymatic s
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019
-
5. Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom
Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic,
Braz J Med Biol Res. Publicado em: 03/12/2018
-
6. Pharmacological characterization of cnidarian extracts from the Caribbean Sea: evaluation of anti-snake venom and antitumor properties
Abstract Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study aimed to evaluate toxicological activities and potential as antitumor and antiophidic agents contained in total extracts from fi
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
-
7. Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms?
Abstract Background Snakes of the genus Bothrops, popularly known as pit vipers, are responsible for most cases of snakebite in Brazil. Within this genus, Bothrops jararacussu and B. jararaca deserve special attention due to the severity of their bites and for inhabiting densely populated areas. Regarding the treatment of snakebites by Bothrops jararacussu
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
-
8. Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2
Abstract Background Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A2 (Lys49-PLA2) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. The C-terminal region of the Lys49-PLA2s is important for these effects; however, the amino acid residues that determine hyperalgesia and e
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 16/03/2017
-
9. Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines
Abstract Background Phospholipases A 2 (PLA 2 s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms. This study aimed to assess the antitumor potential of BthTX-I, a basic myotoxic PLA 2isolated from Bothrops jararacussu venom, by evaluating in vitro pro
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 22/12/2015
-
10. Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes. The present study aimed to assess whether Bothrops jararacussuand Bothrops pirajai crude venoms and their isolated toxins, namely serine
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
-
11. Caryospora bigenetica (Apicomplexa: Eimeriidae) na América do Sul: Registro de novos hospedeiros e distribuição
O coccídio Caryospora bigenetica foi descrito na serpente Crotalus horridus (Viperidae) nos Estados Unidos da América. Este estudo representa o primeiro registro da ocorrência de C. bigenetica em serpentes da América do Sul. Amostras de fezes foram obtidas, entre novembro de 2013 e maio de 2014, de 256 serpentes silvestres mantidas em um criatório cient
Rev. Bras. Parasitol. Vet.. Publicado em: 2015-03
-
12. Diagnóstico parasitológico e imunológico em fezes de serpentes cativas do Instituto Vital Brazil
Foram analisadas amostras fecais de 56 serpentes do Instituto Vital Brazil, Niterói, Rio de Janeiro, por técnicas de sedimentação e flutuação, para pesquisa de formas evolutivas de parasitos como helmintos e protozoários, e imunoenzimáticas para detecção de antígenos de Cryptosporidium sp. e Giardia sp. Dos animais estudados, 80,3% foram positivos
Rev. Bras. Parasitol. Vet.. Publicado em: 23/05/2014