Butyrolactone I
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Efeito da pré-maturação sobre o desenvolvimento embrionário de oócitos submetidos à ativação partenogenética e transferência de núcleo / Effect of pre-maturation on embryo development of oocytes submitted to parthenogenetic activation and nuclear transfer
Embryo production rates obtained from both IVF (30-40%) and NT (23%) are still below the expected values. Therefore, oocyte pre-maturation using cell cycle inhibitors is one of the alternatives which has been studied to increase the competence of oocytes used for IVP, as an attempt to optimize the success rates of these biotechniques. Neurotrophins are known
Publicado em: 2009
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2. The use of computational chemistry in the studies of chemical processes involved in electrospray ionization / A utilização da química computacional em processos químicos relacionados à ionização por electrospray
In recent decades, the development of atmospheric ionization techniques improved mass spectrometry, principally for characterization and structural elucidation of high-molecular weight compounds. The development of spray ionization was responsible for the spread of applications and studies of mass spectrometry, where the electrospray ionization is the most v
Publicado em: 2009
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3. Effect of meiosis block on expression, activity and distribution of meiosis promoting factor (MPF) and mitogen-activated protein kinase (MAPK) in bovine oocytes / Efeito do bloqueio meiótico na expressão, atividade e distribuição do fator promotor da meiose (MPF) e da proteína cinase ativada por mitógenos (MAPK) em oócitos bovinos
Apesar dos grandes avanços na produção in vitro (PIV) de embriões bovinos, a produção de blastocistos se mantém ainda aquém do observado in vivo, indicando que melhorais ainda são necessárias no processo de PIV. A competência para o desenvolvimento de oócitos tem sido relacionada, entre outros fatores, à interrupção do período de capacitaçã
Publicado em: 2008
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4. Study about the synthesis of autoregulators butyrolactones of the Streptomyces bacteria. / Estudos sobre a síntese de butirolactonas auto-reguladoras de bactérias Streptomyces.
Streptomycetes are Gram-positive filamentous bacteria well known for the ability to produce a wide variety of secondary metabolites and biologically active substances. These activities are controlled by low-molecular-weight compounds called butyrolactone autoregulators. The greater number of these compounds with autoregulators properties have as common chara
Publicado em: 2007
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5. Activity of the nitric oxide synthase/nitric oxide system in bovine oocytes / Atividade do sistema óxido nítrico sintase/óxido nítrico em oócitos bovinos
Nitric oxide (NO) is a chemical messenger detected in several cell types such as endothelial cells, neurons and macrophages, performing also varied functions as vasodilatation, neurotransmission and induction of cell death. NO is generated by the activity of the enzyme nitric oxide synthase (NOS), which has been detected in several organs including the repro
Publicado em: 2007
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6. Effect of Butyrolactone I on the Producing Fungus, Aspergillus terreus†
Butyrolactone I [α-oxo-β-(p-hydroxyphenyl)-γ-(p-hydroxy-m-3,3-dimethylallyl-benzyl)-γ-methoxycarbonyl-γ-butyrolactone] is produced as a secondary metabolite by Aspergillus terreus. Because small butyrolactone-containing molecules act as self-regulating factors in some bacteria, the effects of butyrolactone I on the producing organism were studied; speci
American Society for Microbiology.
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7. In Vitro Analysis of the Butyrolactone Autoregulator Receptor Protein (FarA) of Streptomyces lavendulae FRI-5 Reveals that FarA Acts as a DNA-Binding Transcriptional Regulator That Controls Its Own Synthesis
FarA of Streptomyces lavendulae FRI-5 is a specific receptor protein for IM-2, a butyrolactone autoregulator that controls the production of a blue pigment and the nucleoside antibiotics showdomycin and minimycin. Gel shift assays demonstrated that FarA binds to the farA upstream region and that this binding is abolished in the presence of IM-2. The FarA bin
American Society for Microbiology.
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8. Characterization of Binding Sequences for Butyrolactone Autoregulator Receptors in Streptomycetes
BarA of Streptomyces virginiae is a specific receptor protein for a member of butyrolactone autoregulators which binds to an upstream region of target genes to control transcription, leading to the production of the antibiotic virginiamycin M1 and S. BarA-binding DNA sequences (BarA-responsive elements [BAREs]), to which BarA binds for transcriptional contro
American Society for Microbiology.
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9. Behavioral Effects of γ-Hydroxybutyrate, Its Precursor γ-Butyrolactone, and GABAB Receptor Agonists: Time Course and Differential Antagonism by the GABAB Receptor Antagonist 3-Aminopropyl(diethoxymethyl)phosphinic Acid (CGP35348)
γ-Hydroxybutyrate (GHB) is used therapeutically and recreationally. The mechanism by which GHB produces its therapeutic and recreational effects is not entirely clear, although GABAB receptors seem to play an important role. This role could be complex, because there are indications that different GABAB receptor mechanisms mediate the effects of GHB and
American Society for Pharmacology and Experimental Therapeutics.
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10. Gene Replacement Analysis of the Streptomyces virginiae barA Gene Encoding the Butyrolactone Autoregulator Receptor Reveals that BarA Acts as a Repressor in Virginiamycin Biosynthesis
Virginiae butanolides (VBs), which are among the butyrolactone autoregulators of Streptomyces species, act as a primary signal in Streptomyces virginiae to trigger virginiamycin biosynthesis and possess a specific binding protein, BarA. To clarify the in vivo function of BarA in the VB-mediated signal pathway that leads to virginiamycin biosynthesis, two bar
American Society for Microbiology.
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11. Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
Cyclin-dependent kinase 5 (Cdk5) is a multifunctional neuronal protein kinase that is required for neurite outgrowth and cortical lamination and that plays an important role in dopaminergic signaling in the neostriatum through phosphorylation of Thr-75 of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, molecular mass 32 kDa). Casein kinase 1 (CK1)
The National Academy of Sciences.
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12. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs through a selective interaction with the glycine modulatory site within the receptor complex. When the enantiomers of (+/-)-HA-966 were resolved, the (R)-(+)-enantiomer was found to be a selective glycine/NMDA receptor antagonist, a prop