Calixarenes
Mostrando 1-7 de 7 artigos, teses e dissertações.
-
1. Calix[6]arene, a novel compound acting as a strong inhibitor of the low molecular weight protein tyrosine phosphatase.
Calix[6]arene is a macrocyclic compound of phenolic units linked by methylene group at the 2,6-positions. Besides being used as platform for the development of new drugs and as a carrier of drugs, recently some important pharmacological properties of calixarenes have been reported. The goal of this work was to examine the effect of calix[6]arene on the low m
REUNIÃO ANUAL DA SOCIEDADE BRASILEIRA DE BIOQUÍMICA E BIOLOGIA MOLECULAR ? SBBq. Publicado em: 2011
-
2. Modulação de vias de sinalização para indução de morte de células leucêmicas / Modulation of signaling pathways for death induction of leukemia cells
A eficiência do tratamento da leucemia sob vários aspectos, mesmo com os avanços farmacotecnológicos, ainda permanece como desafio para a medicina. Diante desse fator, maiores informações sobre a base molecular da leucemia e o desenvolvimento de agentes que atuem de forma alvo-específico, apresentem poucos efeitos colaterais e possam impedir o escape
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/07/2010
-
3. Encapsulamento de moléculas bioativas com calix[n]arenos e avaliação da atividade fitotóxica de complexos de inclusão com aldiminas / Encapsulation of bioactive molecules with calix[n]arenes and evaluation of phytotoxic activity the inclusion complexes with aldimines
This research had as main objective to study intermolecular interactions using 1H NMR as major tool. The first chapter describes the synthesis of six molecules, two of them employed as molecular hosts: p-sulphonic acid calix[6]arene (SO3HCX[6]) (3) and p-sulphonic acid calix[4]arene (SO3HCX[4]) (6). The calixarenes synthesized were employed in the encapsulat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/07/2009
-
4. "Estudo do processo de complexação de calixarenos com íons metálicos e espécies neutras por simulações de dinâmica molecular" / A study of the complexation process of calixarenes with metallic ions and neutral species from molecular dynamic simulations
We report a series of Molecular Dynamics simulations, in vacuum and in acetonitrile solution, on the complexation process of the calixarens tetraethylester p-tert-butyl calix[4]arene (CLE) and tetramethylketone p-tert-butyl calix[4]arene (CLC) with Pb2+ and Cd2+ anions and neutral species. The solvent and calixarene molecules were modeled based on the OPLS-A
Publicado em: 2006
-
5. STUDY OF THE ELECTROCHEMICAL BEHAVIOR OF SAME CALIXARENES IN THE PRESENT OF IONS METALS / ESTUDO DO COMPORTAMENTO ELETROQUÍMICO DE ALGUNS CALIXARENOS EM PRESENÇA DE ÍONS METÁLICOS
The study of the electrochemical behavior of electrodes of carbon paste chemically modified with the following calixarenes: 4-sulf- calix[4]arene and 4-terc-butilcalix[4,6,8]arene was investigated in the present of cations (Sb3+, Se4+, Mn2+, Cd2+, Zn2+, Cu2+, Pb2+, V4+ and V5+) using differential pulse , square wave and cyclical voltammetry. Other electroche
Publicado em: 2005
-
6. Antimycobacterial Calixarenes Enhance Innate Defense Mechanisms in Murine Macrophages and Induce Control of Mycobacterium tuberculosis Infection in Mice
Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some of which are able to modify the growth of
American Society for Microbiology.
-
7. Calixarenes with host-mediated potency in experimental tuberculosis: further evidence that macrophage lipids are involved in their mechanism of action.
Some time ago, it was found that attachment of hydrophilic polyoxyethylene chains to various hydrophobic phenols and alcohols gave water-soluble products which, although inactive in vitro, influenced and experimental tuberculous infection. With short chains the infection was suppressed, and with long chains it was promoted. Later work concentrated on Macrocy