Calloselasma Rhodostoma
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. l-Amino acid oxidase isolated from Calloselasma rhodostoma snake venom induces cytotoxicity and apoptosis in JAK2V617F-positive cell lines
ABSTRACT BACKGROUND: Myeloproliferative neoplasms are Philadelphia chromosome-negative diseases characterized by hyperproliferation of mature myeloid cells, associated or not with the Janus kinase 2 tyrosine kinase mutation, JAK2V617F. As there is no curative therapy, researchers have been investigating new drugs to treat myeloproliferative neoplasms, incl
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-06
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2. Comparative analysis of the venom proteome of four important Malaysian snake species
Background Naja kaouthia, Ophiophagus hannah, Bungarus fasciatus and Calloselasma rhodostoma are four venomous snakes indigenous to Malaysia. In the present study, their proteomic profile by two-dimensional gel electrophoresis (2-DE) have been separated and compared. Results The 2-DE of venoms of the four species snake demonstrated complexity and obvious
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 04/03/2014
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3. Cytotoxicity of Southeast Asian snake venoms
Cytotoxicity of venoms from eleven medically important snakes found in Southeast Asia (Naja kaouthia, Naja siamensis, Naja sumatrana, Ophiophagus hannah, Bungarus candidus, Bungarus fasciatus, Enhydrina schistosa, Calloselasma rhodostoma, Trimeresurus purpureomaculatus and Tropidolaemus sumatranus) was determined, based on the MTS cytotoxicity assay, which d
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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4. The concept of two-dimensional electrophoresis-guided purification proven by isolation of rhodocetin from Calloselasma rhodostoma (Malayan pit viper)
Two-dimensional gel electrophoresis (2DE) is an important tool for investigating the complexity of snake venom proteomes. Apart from applications based on whole proteome analysis, we suggest that 2DE can be used as an assay to guide the progress of protein purification. The aim of this study was to prove the feasibility of this concept by using it to purify
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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5. Enzymatic and toxinological activities of Hypnale hypnale (hump-nosed pit viper) venom and its fractionation by ion exchange high performance liquid chromatography
Hypnale hypnale (hump-nosed pit viper) has been recently identified as one of the medically important venomous snakes in Sri Lanka and on the southwestern coast of India. The characterization of its venom is essential for understanding the pathophysiology of envenomation and for optimizing its management. In the present study, the biological properties of Hy
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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6. Protein profile analysis of Malaysian snake venoms by two-dimensional gel electrophoresis
Snake venoms comprise a highly complex mixture of proteins, which requires for their characterization the use of versatile two-dimensional electrophoresis techniques. In the present study, venoms obtained from eight snakes (Ophiophagus hannah, Naja kaouthia, Naja sumatrana, Bungarus fasciatus, Trimeresurus sumatranus, Tropidolaemus wagleri, Enhydrina schisto
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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7. Serum kinetics of Calloselasma rhodostoma (Malayan pit viper) venom components in a rabbit
The serum kinetics of Calloselasma rhodostoma (Malayan pit viper) venom - specifically two of its components, the major hemorrhagin (rhodostoxin) and a thrombin-like enzyme - was examined in a rabbit by double-sandwich enzyme-linked immunosorbent assay (ELISA). The animal received intramuscularly a 1.0-mg/kg dose of C. rhodostoma venom. The venom level in se
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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8. Studies structure-function of phospholiphse A IND. 2 D49 and K49 homologue purified from Bothrops jaracussu and Calloselasma rhodostoma : analyse comparative structure and function / Estudos estrutura-função de fosfolipases A IND. 2 D49 e K49 homologa isoladas do veneno de Bothrops jaracussu e Calloselasma rhodostoma : analise comparativa estrutural e biologica
O envenenamento ofídico é um evento comum nos países pobres da área tropical e subtropical e as conseqüências deste, muito graves. Nestes países, pequena têm sido a valorização destas conseqüências, sendo pouco registradas estatisticamente como casos de saúde pública e muitas vezes tratados com procedimentos pouco efetivos ou ultrapassados. Nes
Publicado em: 2008
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9. The structure of l-amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site
The structure of l-amino acid oxidase (LAAO) from Calloselasma rhodostoma has been determined to 2.0 Å resolution in the presence of two ligands: citrate and o-aminobenzoate (AB). The protomer consists of three domains: an FAD-binding domain, a substrate-binding domain and a helical domain. The interface between the substrate-binding and helical domains f
Oxford University Press.