Camkii
Mostrando 1-12 de 78 artigos, teses e dissertações.
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1. Analgesic effects of Marasmius androsaceus mycelia ethanol extract and possible mechanisms in mice
Marasmius androsaceus is a medicinal fungus mainly used to treat various forms of pain in China. This study investigated the analgesic effects of an ethanol extract of M. androsaceus (MAE) and its potential molecular mechanisms. Oral administration of MAE (50, 200, and 1000 mg/kg) had significant analgesic effects in an acid-induced writhing test, a formalin
Braz J Med Biol Res. Publicado em: 01/03/2018
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2. Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation
Ca2+ pumps are important players in smooth muscle contraction. Nevertheless, little information is available about these pumps in the vas deferens. We have determined which subtype of sarco(endo)plasmic reticulum Ca2+-ATPase isoform (SERCA) is expressed in rat vas deferens (RVD) and its modulation by calmodulin (CaM)-dependent mechanisms. The thapsigargin-se
Braz J Med Biol Res. Publicado em: 19/03/2013
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3. The role of Ca2+/calmodulin-dependent protein kinase II and calcineurin in TNF-α-induced myocardial hypertrophy
We investigated whether Ca2+/calmodulin-dependent kinase II (CaMKII) and calcineurin (CaN) are involved in myocardial hypertrophy induced by tumor necrosis factor α (TNF-α). The cardiomyocytes of neonatal Wistar rats (1-2 days old) were cultured and stimulated by TNF-α (100 μg/L), and Ca2+ signal transduction was blocked by several antagonists, including
Braz J Med Biol Res. Publicado em: 2012-11
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4. Diabetes abolishes the \ \ in vitro\ \ muscle contraction-induced increase in SLC2A4 gene expression. Participation of AMPK and CAMKII kinases and MEF2D, GEF, HIF-1a and TRa1 transcriptional factors. / O diabetes abole o aumento da expressão do gene SLC2A4 induzido pela contração muscular \"in vitro\": participação das cinases AMPK E CAMKII e dos fatores transcricionais MEF2D, GEF, HIF-1a e TRa.
O gene SLC2A4 codifica a proteína GLUT4, fundamental na homeostasia glicêmica. OBJETIVO: Investigar o efeito do diabetes na expressão do GLUT4 pela atividade contrátil. MÉTODOS: Músculos sóleos de ratos não diabéticos (ND) e diabéticos tratados com insulina (DI) ou salina (DS) foram incubados e contraídos. A expressão de GLUT4, pAMPK e CAMKII for
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/08/2011
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5. Os exercícios aeróbio e resistido melhoram a memória espacial de ratos por mecanismos diferentes / Spatial memory is improved by aerobic and resistance exercise through different mechanisms
As evidências científicas que se acumulam ao longo do tempo mostram o impacto positivo do exercício físico para a saúde humana, em especial para a saúde cerebral. Os efeitos como o aumento da atividade neurotrófica do BDNF e do IGF-1, devido ao exercício físico aeróbio, parecem influenciar os neurônios do hipocampo, e estão associados com a melho
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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6. Proteína quinase C (PKC) e proteína quinase dependente de cálcio/calmodulina (CaMK II) na ativação de oócitos bovinos / Protein kinase C (PKC) and Calcium/calmodulin-dependent protein kinase II (CaMKII) in bovine oocyte activation
A fecundação resulta no aumento intracelular de cálcio que é necessário para a transição do oócito até o estádio de zigoto. Os eventos que ocorrem durante esta transição são caracterizados como ativação, sendo estes dependentes de cálcio. Entretanto, os eventos bioquímicos que ocorrem durante a ativação ainda não estão completamente eluc
Publicado em: 2010
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7. The involvement of protein kinases on spatial learning enhancement induced by creatine / O envolvimento de proteínas quinases na facilitação do aprendizado espacial induzido por creatina
Decline cognitive related to neurodegenerative diseases are very commom in patients, probably in function of aging. Since there are few effectives therapeutics approaches to loss memory treatment, but studies about new therapeutics approaches are necessary regarding neuroprotective drugs. Thus, recent works have been showing the efficacy of some neuroprotect
Publicado em: 2009
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8. Células tronco tumorais e o sistema purinérgico
Gliomas são os tumores mais comuns no SNC, apresentando altas taxas de invasibilidade e proliferação, resistência à quimio e radioterapias, e elevados índices de recorrência e morte. As células-tronco tumorais constituem uma minoria dentre as células do tumor, apresentam características de células tronco neurais podendo sofrer diferenciação e au
Publicado em: 2009
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9. Flavins promote changes in the extracellular matrix, signal transduction, antioxidant enzymes and metalloproteinases during osteoblast differentiation / Flavinas promovem mudanças na matriz extracelular, vias de transdução de sinal, enzimas antioxidantes e metaloproteinases durante a diferenciação de osteoblastos
Riboflavin (Rb-Vitamin B2) is the precursor of essential flavocoenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes participate in numerous enzymatic processes dependent on electron transfer reactions that occur in energyproducing, biosynthetic, and detoxifying and electron-scavenging pathways. Increase dietary ribofla
Publicado em: 2009
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10. Avaliação neuroquímica do sistema colinérgico de camundongos com o gene do transportador vesicular de acetilcolina (VAChT) modificado geneticamente
The vesicular acetylcholine transporter (VACht) is responsible for acetylcholine (Ach) storage in synaptic vesicles, an important step for cholinergic transmission. Our goal was to study the role of VAChT in cholinergic tonus maintenance through the generation of mice presenting alterations in VAChT gene by homologous recombination.. One of used strategies w
Publicado em: 2008
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11. The importance of the Thr17 residue of phospholamban as a phosphorylation site under physiological and pathological conditions
The sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) is under the control of an SR protein named phospholamban (PLN). Dephosphorylated PLN inhibits SERCA2a, whereas phosphorylation of PLN at either the Ser16 site by PKA or the Thr17 site by CaMKII reverses this inhibition, thus increasing SERCA2a activity and the rate of Ca2+ uptake by the SR. This leads to
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-05
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12. CaMKIIdelta overexpression in hypertrophy and heart failure: cellular consequences for excitation-contraction coupling
Ca/calmodulin-dependent protein kinase IIdelta (CaMKIIdelta) is the predominant isoform in the heart. During excitation-contraction coupling (ECC) CaMKII phosphorylates several Ca-handling proteins including ryanodine receptors (RyR), phospholamban, and L-type Ca channels. CaMKII expression and activity have been shown to correlate positively with impaired e
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-09