Cancer Cells Variability
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Non-homologous DNA end joining in normal and cancer cells and its dependence on break structures
DNA double-strand breaks (DSBs) are a serious threat to the cell, for if not or miss-repaired, they can lead to chromosomal aberration, mutation and cancer. DSBs in human cells are repaired via non-homologous DNA end joining (NHEJ) and homologous recombination repair pathways. In the former process, the structure of DNA termini plays an important role, as do
Genetics and Molecular Biology. Publicado em: 12/03/2010
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2. Modelo matemático de distribuição larga de dose limiar em tumores submetidos a múltiplas sessões de terapia fotodinâmica / Mathematical model for broad distribution of threshold dose in tumors treated with multiple photodynamic therapy sessions
Photodynamic therapy is a well known treatment option for many types of malignant and nonmalignant lesions. This technique causes cell damage through a photochemical reaction, generating oxidative agents responsible for tumor cell killing. In several cases, multiple PDT-sessions are needed to promote cancer eradication. However, several clinical studies have
Publicado em: 2010
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3. Characterization and evolutionary dynamics of endogenous retroviruses K (ERV-K) in primate genomes. / Caracterização e dinâmica evolutiva de retrovírus endógenos da família K (ERV-K) em genomas de primatas.
Endogenous retroviruses (ERVs) are remains of ancient viral infection in the germ line cells and subsequent vertical transmission. The K family are integrated only in humans and the Old World monkeys. ERVs play a fundamental role on genome evolution and foster variability. The aim of this work was to investigate their distribution and evolutionary dynamics i
Publicado em: 2009
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4. Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma
OBJECTIVE: Investigate the possible association of insertion/deletion (2G/G) polymorphism at nucleotide -1607 of the MMP-1 promoter with the development and progression of renal cancer MATERIALS AND METHODS: In this study, we genotyped 217 individuals, 99 patients with renal cell carcinoma (RCC) and 118 controls without cancer. DNA specimens were extracted f
International braz j urol. Publicado em: 2007-10
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5. Immunohistochemical expression of pi class glutathione S-transferase in the basal cell layer of benign prostate tissue following chronic treatment with finasteride.
BACKGROUND: Glutathione S-transferases (GST) may prevent carcinogenesis through inactivation of reactive electrophiles by conjugation to reduced glutathione. Treatment directed at the induction or preservation of GST-pi expression in normal epithelium could have a profound impact on the prevention of prostate neoplasia. Finasteride, a 5-alpha-reductase inhib
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6. Gene expression profiling of melanoma cells – searching the haystack
Cancer is being increasingly recognized as a very heterogeneous disease, both within an individual tumor and within a tumor type and among tumor types. This heterogeneity is manifested both at the genetic and phenotypic level and determines the progression of disease and response to therapy. It is possible to see the heterogeneity in examples of differential
BioMed Central.
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7. Nucleolar organiser regions (AgNORS) in anal intraepithelial neoplasia and invasive anal squamous cell carcinoma.
AIM: To evaluate the usefulness of counting nucleolar organiser region associated proteins (AgNORs) in the management of anal squamous neoplasia. METHOD: Using a silver staining technique for NOR associated proteins, 32 routinely processed paraffin wax embedded sections of anal epithelium were assessed. These consisted of normal anal epithelium (n = 9), anal
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8. Systematic variables affecting simian virus 40-induced T-antigen expression and transformation in human cells.
Simian virus 40 (SV40) infection of human skin fibroblast and human tumor cells resulted in the expression of T-antigen and transformed foci. By examining various conditions of input virus multiplicity and initial cell density, the systematic variation of T-antigen determination was minimized. The most uniform results were obtained at multiplicities of about
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9. In vitro influence of Phaseolus vulgaris, Griffonia simplicifolia, concanavalin A, wheat germ, and peanut agglutinins on HCT-15, LoVo, and SW837 human colorectal cancer cell growth.
BACKGROUND/AIMS: Compared with normal colonic mucosa, lectin receptor expression is increased in hyperplastic and neoplastic tissues; some lectins have been shown to influence human colonic epithelial cell proliferation. The aim was to assess further the influence of five lectins (Phaseolus vulgaris (PNA), Griffonia simplicifolia (GSA), concanavalin A (Con A
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10. Direct evidence to support the immunosurveillance concept in a human regressive melanoma.
The concept of immunosurveillance against cancer has been an extensively debated question over the last decades. Multiple indirect arguments have supported the view that the immune system may control, at least in certain cases, malignant cell growth while direct demonstration is still lacking in the human. In an attempt to address this issue, we have selecte
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11. Tumour heterogeneity of DNA cell cycle variables in breast cancer measured by flow cytometry.
AIM/BACKGROUND: Conflicting results have been reported concerning the prognostic value of DNA flow cytometric variables (DNA ploidy, DNA index, %S phase fraction) in breast cancer. Selection bias and differences in treatment may have contributed to these conflicting prognostic results. Differences in tissue processing, the number of nuclei measured, DNA hist
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12. A novel inward-rectifying K+ current with a cell-cycle dependence governs the resting potential of mammalian neuroblastoma cells.
1. Human and murine neuroblastoma cell lines were used to investigate, by the whole-cell patch-clamp technique, the properties of a novel inward-rectifying K+ current (IIR) in the adjustment of cell resting potential (Vrest), which was in the range -40 to -20 mV. 2. When elicited from a holding potential of 0 mV, IIR was completely inactivated with time cons