Cancer Testis Ct Antigens
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Melanoma: tumor microenvironment and new treatments
Abstract: In the recent past years, many discoveries in the tumor microenvironment have led to changes in the management of melanoma and it is rising up hopes, specially, to those in advanced stages. FDA approved seven new drugs from 2011 to 2014. They are: Vemurafenib, Dabrafenib and Trametinib, kinases inhibitors used for patients that have BRAFV600E mutat
An. Bras. Dermatol.. Publicado em: 2017-03
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2. Caracterização funcional da interação entre as proteínas CTSP-1 e CTCF / Functional characterization of the interaction between the proteins CTSP-1 and CTCF.
Cancer-testis (CT) antigens are immunogenic proteins expressed in gametogenic tissues and in different histological types of tumors, being considered promising candidates for cancer immunotherapy. However, little is known about their role in tumorigenesis. In 2006, we identified CTSP-1 as a novel CT antigen, frequently expressed in different types of tumors.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/12/2011
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3. Expressão de antígenos específicos de câncer/testículo em linfomas. / Expression of cancer/testis antigens in lymphomas.
Os antígenos cancer/testículo (CTAs) são considerados promissores alvos para abordagens de imunoterapia em câncer devido à sua alta imunogenicidade e padrão de expressão praticamente restrito a tecidos tumorais (estão também expressos em células germinativas do testículo, placenta e ovário fetal). Apesar do padrão de expressão dos CTAs estar be
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/08/2010
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4. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library
Cancer/testis (CT) antigens—immunogenic protein antigens that are expressed in testis and a proportion of diverse human cancer types—are promising targets for cancer vaccines. To identify new CT antigens, we constructed an expression cDNA library from a melanoma cell line that expresses a wide range of CT antigens and screened the library with an allogen
The National Academy of Sciences.
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5. Immunomic analysis of human sarcoma
The screening of cDNA expression libraries from human tumors with serum antibody (SEREX) has proven to be a powerful method for identifying the repertoire of tumor antigens recognized by the immune system of cancer patients, referred to as the cancer immunome. In this regard, cancer/testis (CT) antigens are of particular interest because of their immunogenic
The National Academy of Sciences.