Cardiac Electrophysiology Modeling
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. MODELING OF THE CARDIAC ELECTRODYNAMICS AND OF THE EFFECTS OF SPATIAL AND TIME RESOLUTION ON OPTICAL MAPS / MODELAGEM DA ELETRODINÂMICA CARDÍACA E DOS EFEITOS DA RESOLUÇÃO ESPACIAL E TEMPORAL EM MAPAS ÓPTICOS
Fluorescence studies using potentiometric dyes to optically measure the action potential of cardiac cells constitute an important tool to better understand the electrophysiology of the heart. However, in many experimental setups, the finite sensing area of optical detectors cannot be neglected. As a consequence, the detected fluorescence signal may effective
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/02/2011
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2. Modelagem da Microestrutura de Tecidos Cardíacos
A few decades ago the cardiac tissue was believed to be an uniformly connected continumm. Currently, it is known that the cardiac cells are connected to each other via special protein channels called gap junctions, through which the ionic current flows between neighboring cells. The cardiac cells are arranged in distinct layers of muscle fibers surrounded by
Publicado em: 2011
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3. Ajuste automático de modelos celulares apoiado por Algoritmos Genéticos
The modeling of the electrical activity of the heart is of great medical and scientific interest, because it provides a way for a better understanding of the related biophysical phenomena and it allows the development of new techniques for diagnoses, as well as new drugs. The current mathematical models are usually based on experimental data obtained from a
Publicado em: 2008
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4. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval
Regulatory subunit KCNE3 (E3) interacts with KCNQ1 (Q1) in epithelia, regulating its activation kinetics and augmenting current density. Since E3 is expressed weakly in the heart, we hypothesized that ectopic expression of E3 in cardiac myocytes might abbreviate action potential duration (APD) by interacting with Q1 and augmenting the delayed rectifier curre
American Society for Clinical Investigation.