Cardiac Embryogenesis
Mostrando 1-12 de 38 artigos, teses e dissertações.
-
1. Retinoic acid signaling and the evolutionary origins of cardiac chambers. / A sinalização pelo ácido retinóico e a origem evolutiva das câmaras cardíacas.
Nos últimos anos, nós propusemos um modelo de duas etapas para a padronização antero-posterior do coração. Ácido retinóico (AR) produzido pela enzima RALDH2 induz o destino sino atrial nos precursores cardíacos posteriores. Subsequentemente, estes precursores adquirem a capacidade de expressar RALDH2, formando uma onda caudo-rostral desta enzima. A
Publicado em: 2009
-
2. Caracterização das funções do gene ring finger 4 na embriogênese cardíaca
Cardiac diseases, whether congenital or acquired, show a high mortality rate worldwide and in Brazil, they represent the major cause in natural deaths with 29.9% of the cases. The social and economical impact of those pathologies on the Brazilian Public Health System is particularly worsened due to the lack of resources and the need to optimize the scarce re
Publicado em: 2006
-
3. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins
The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fiber gene expression in skeletal muscle. To identify proteins that mediate the effects of calcineurin on striated muscles, we used the calcineurin catalytic subunit in a two-hyb
The National Academy of Sciences.
-
4. Analysis of mRNAs under translational control during Xenopus embryogenesis: isolation of new ribosomal protein clones.
We have analyzed several randomly selected mRNAs, of the relatively abundant category, on the basis of maternal or zygotic origin and translational efficiency at different developmental stages. For this purpose, clones from a Xenopus embryo cDNA library were hybridized with cDNA probes prepared with poly(A)+RNA from polysomes and from mRNPs of embryos at dif
-
5. A Dual Role of the GTPase Rac in Cardiac Differentiation of Stem Cells
The function of the GTPase Rac1, a molecular switch transducing intracellular signals from growth factors, in differentiation of a specific cell type during early embryogenesis has not been investigated. To address the question, we used embryonic stem (ES) cells differentiated into cardiomyocytes, a model that faithfully recapitulates early stages of ca
The American Society for Cell Biology.
-
6. Complete heart block and sudden death in mice overexpressing calreticulin
The expression of calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum, is elevated in the embryonic heart, and because of impaired cardiac development, knockout of the Calreticulin gene is lethal during embryogenesis. The elevated expression is downregulated after birth. Here we have investigated the physiological consequences of continued hi
American Society for Clinical Investigation.
-
7. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
Epithelial–mesenchymal transformation is a critical developmental process reiterated in multiple organs throughout embryogenesis. Formation of endocardial cushions, primordia of valves and septa, is a classic example of epithelial–mesenchymal transformation. Several gene mutations are known to affect cardiac valve formation. Sox9 is activated when endoca
National Academy of Sciences.
-
8. Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers
A regular heart beat is dependent on a specialized network of pacemaking and conductive cells. There has been a longstanding controversy regarding the developmental origin of these cardiac tissues which also manifest neural-like properties. Recently, we have shown conclusively that during chicken embryogenesis, impulse-conducting Purkinje cells are recruited
The National Academy of Sciences.
-
9. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination throughout metazoan evolution, and overexpression of activating alleles is oncogenic in mammals. Here we demonstrate that Notch activity promotes EMT during both cardiac development
Cold Spring Harbor Laboratory Press.
-
10. Hypertension in mice lacking the proatrial natriuretic peptide convertase corin
Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure. In cardiomyocytes, the hormone is synthesized as a precursor, proatrial natriuretic peptide (pro-ANP), which is proteolytically converted to active ANP. Corin is a cardiac transmembrane serine protease that has been shown to process pro-ANP in vitro, but its physiological im
National Academy of Sciences.
-
11. Cytoplasmic Thioredoxin Reductase Is Essential for Embryogenesis but Dispensable for Cardiac Development
Two distinct thioredoxin/thioredoxin reductase systems are present in the cytosol and the mitochondria of mammalian cells. Thioredoxins (Txn), the main substrates of thioredoxin reductases (Txnrd), are involved in numerous physiological processes, including cell-cell communication, redox metabolism, proliferation, and apoptosis. To investigate the individual
American Society for Microbiology.
-
12. The c-myc proto-oncogene regulates cardiac development in transgenic mice.
During the maturation of the cardiac myocyte, a transition occurs from hyperplastic to hypertrophic growth. The factors that control this transition in the developing heart are unknown. Proto-oncogenes such as c-myc have been implicated in the regulation of cellular proliferation and differentiation, and in the heart the switch from myocyte proliferation to