Cardiolipin
Mostrando 1-12 de 312 artigos, teses e dissertações.
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1. Identification of a Novel TAZ Gene Mutation in a Family With X-Linked Dilated Cardiomyopathy Barth Syndrome
Abstract Mutations in the tafazzin (TAZ) gene on chromosome Xq28 are responsible for the Barth syndrome (BTHS) phenotype resulting in a loss of function in the protein tafazzin involved in the transacylation of cardiolipin, an essential mitochondrial phospholipid. TAZ gene was investigated in the proband in our study, who died of dilated cardiomyopathy at 8
J. inborn errors metab. screen.. Publicado em: 19/06/2019
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2. Mecanismos moleculares da ação tóxica pró-oxidante de 1,4-diamino-2-butanona, um análogo de putrescina, sobre células de mamíferos e Trypanosoma cruzi / The Molecular mechanisms of pro-oxidant activity of 1,4-diamino-2-butanone, a putrescine analogue, to mammalian cells and Trypanosoma cruzi
α-Aminocarbonyl componds such as 5-aminolevunilic acid (ALA) and aminoacetone (AA) have been shown to exhibit pro-oxidant properties. These compounds undergo phosphate-catalyzed enolization in physiological pH and subsequent aerobic oxidation, yielding reactive oxygen species, NH4+ ions and an α-oxoaldehyde highly cytotoxic. The α-aminoketone 1
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/06/2012
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3. Lepromatous leprosy patients produce antibodies that recognise non-bilayer lipid arrangements containing mycolic acids
Non-bilayer phospholipid arrangements are three-dimensional structures that form when anionic phospholipids with an intermediate structure of the tubular hexagonal phase II are present in a bilayer of lipids. Antibodies that recognise these arrangements have been described in patients with antiphospholipid syndrome and/or systemic lupus erythematosus and in
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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4. Fotossensibilização de vesículas lipídicas gigantes / Giant Lipid Vesicles Photosensibilization
A Terapia Fotodinâmica é um tratamento promissor no cura de várias doenças oftalmológicas e dermatológicas, assim como tumores. Este tratamento utiliza a combinação de luz e um composto fotossensível na presença de oxigênio. Neste trabalho objetivamos entender mecanismos de fotossensibilização em membranas. Para isso, estudamos os efeitos de irr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
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5. Efeitos do tratamento ácido no inóculo sobre a produção e massa molar do ácido hialurônico / Effects of the acid stress in the inoculum on the production and molecular weight of hyaluronic acid
Hyaluronic acid (HA) is a polysaccharide composed of 2000-25000 disaccaridic units of glucuronic acid and N-acetylglucosamine ?-bonds formed by 1-3 and 1-4 ?-turn. Due its physicochemical properties such as lubricity, hydrophilic and biocompatible, HA has been widely applied in the medical field. Many Studies show that production of HA by fermentation microb
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/10/2011
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6. Structure-biochemical aspects of adenine nucleotide translocase, cardiolipin and ciclophilin D on Ca2+-induced mitochondrial permeability transition / Aspectos bioquímico-estruturais do transportador de nucleotídeos de adenina, cardiolipinas e ciclofilina D na transição de permeabilidade mitocondrial induzida por Ca2+
Oxidation of the Adenine Nucleotide Translocase (ANT) cysteine residue 56 (ANT-cys56) is potentially involved in Ca2+-induced Mitochondrial Permeability Transition (MPT), a process which is prevented by cyclosporine A (CsA), due to its inhibition of Permeability Transition Pore (PTP) opener component, the peptidyl-prolyl cis-trans isomerase cyclophylin D (cy
Publicado em: 2010
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7. Evaluation of the protective effect of carvedilol against the renal mitochondrial toxicity induced by cisplatin in rats / Avaliação do efeito protetor do carvedilol na toxicidade mitocondrial renal induzida pela cisplatina em ratos
Cisplatin (cis-diamminedichloridoplatinum II) is an affective anticancer agent; however its clinical use is highly limited, predominantly due to its nephrotoxicity. Many studies have shown that cisplatin cause mitochondrial dysfunction in renal epithelial cells due to the generation of reactive oxygen species, such as superoxide anions and hydroxyl radicals.
Publicado em: 2009
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8. Antiphospholipid antibodies in Brazilian hepatitis C virus carriers
Hepatitis C, a worldwide viral infection, is an important health problem in Brazil. The virus causes chronic infection, provoking B lymphocyte dysfunction, as represented by cryoglobulinemia, non-organ-specific autoantibody production, and non-Hodgkin's lymphoma. The aim of this research was to screen for the presence of antiphospholipid autoantibodies in 10
Brazilian Journal of Medical and Biological Research. Publicado em: 31/05/2008
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9. Patogênese da síndrome pulmonar hemorrágica na leptospirose humana / Pathogenesis of leptospirosis pulmonary hemorrhage syndrome in human
Leptospirosis is a zoonotic disease that is a cause of high morbidity and mortality in humans and is an important public health problem. Caused by bacteria of Leptospira genus, this disease presents diverse clinical manifestations and is especially important in developing countries. Leptospirosis pulmonary hemorrhage syndrome is the major cause of death in p
Publicado em: 2008
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10. Development of membrane biosensors and characterization of the interactions between cytochrome c and hybrid bilayer membranes by Surface Plasmon Resonance / Desenvolvimento de biosensores de membranas e caracterização da interação entre citocromo c e bicamadas híbridas por ressonância plasmônica de superfície
The aim of this work was to develop membrane biosensors based on Surface Plasmon Resonance (SPR) and to apply them to study the interactions between cytochrome c (cyt c) and model membranes. SPR is an optical technique that provides high-sensitivity measurements of refractive index (n), allowing the characterization of the adsorption and desorption of molecu
Publicado em: 2008
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11. Detection of anti-cardiolipin antibodies from real sera using polymerized liposomes / Detecção de anticorpos anti-cardiolipidina em soros reais utilizando lipossomas polimerizados
This work studies the detection of anticardiolipin IgG present in the sera o patients with autoimmune diseases , using polymerized liposomes. The advantage of this system is the molecular recognition and transduction of signal in a single step. The use of real sera, instead reference sera, aimed to evaluate the potentiality of polymerized liposomes to applic
Publicado em: 2007
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12. Aterosclerose na artrite reumatóide e sua associação com auto-imunidade humoral / Atherosclerosis in rheumatoid arthritis and its relationship with humoral autoimmunity
Purpose: Many questions remain unanswered about the causes of accelerated atherosclerosis in patients with inflammatory systemic diseases such as rheumatoid arthritis (RA). Some studies have suggested the role of autoimmunity besides inflammation in the pathogenesis of atherosclerosis in general population and have also discussed the possible association wit
Publicado em: 2007