Cationic Liposomes
Mostrando 1-12 de 68 artigos, teses e dissertações.
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1. Desenvolvimento de processo microfluídico para incorporação de DNA em lipossomas catiônicos destinados a terapia e vacinação gênica = : Development of microfluidic process for DNA incorporation into cationic liposomes for gene therapy and vaccination / Development of microfluidic process for DNA incorporation into cationic liposomes for gene therapy and vaccination
This research aimed at the technological development of microfluidic process for nonviral carriers production based on the electrostatic complexation between cationic liposomes (CL) and plasmidal DNA (pDNA) for gene and vaccine therapy applications. The development of this process was compared to the conventional bulk process, in which the solutions are mixe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2012
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2. Desenvolvimento de nanosistemas farmacêuticos para terapia gênica
A terapia gênica é um dos maiores desafios propostos pela pesquisa pós-genômica e se baseia na transferência de material genético a uma célula, tecido ou órgão com o intuito de curar ou melhorar o estado clínico do paciente. Em sua forma mais simples, a terapia gênica consiste na inserção de genes funcionais em células com genes defeituosos obj
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/03/2011
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3. A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
Cationic liposomes are an alternative to DNA non-viral carrier in gene therapy, promoting higher efficiency for transport and delivery into the cells. Liposome production large scale is still a challenge. Among many processes, from dried film adsorbed inside multitubular system promising due its operational simplicity. this field, engineering contributions s
Brazilian Journal of Chemical Engineering. Publicado em: 2007-12
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4. Estudo do Segmento Consenso Adjacente ao Domínio TM2 e parte do Domínio TM2 do Receptor P2X7: Dinâmica Molecular e Atividade de Canal Iônico. / Study of the segment adjacent consensus to domain TM2 and part of domain TM2 of receiver P2X7: molecular dynamics and activity of ionic canal.
The purinergic receptor P2X7 (P2X7R) is a membrane protein which forms channels in the presence of extracellular ATP. Once opened, the channels allow the transport of cations through the cellular membrane, being expressed preferentially in immune cells. Among all purinergic receptors, P2X7R has distinct characteristics from other P2X (P2XR) members. For exam
Publicado em: 2007
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5. "Propriedades estruturais de agregados anfifílicos catiônicos: interação com material genético" / structural properties of cationic amphiphilic aggregates: interaction with genetic material
Though less efficient than viral vectors, cationic lipids have been used as carriers in gene therapy. They offer several advantages over viral vectors, including the low immunogenic and inflammatory responses, the potential transfer of unlimited-size expression units, and the possibility for engineered cell-specific targeting. However, the interaction betwee
Publicado em: 2006
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6. Lipid adjuvants as carriers for tuberculosis DNA vaccine / Desenvolvimento de vacina genica veiculada em adjuvantes lipidicos para tratamento da tuberculose
Este trabalho visa o desenvolvimento tecnológico de uma vacina gênica, destinada ao combate à tuberculose, na qual o DNA encontra-se veiculado em lipossomas. Foram enfocados três aspectos principais: 1.A preparação e caracterização de estruturas lipídicas funcionais veiculando o DNA, projetadas para atenderem aos requisitos de imunização contra a
Publicado em: 2006
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7. Porphyrins derivatives as photosensitizers for photodynamic therapy / Derivados porfirínicos como fotossensibilizadores para terapia fotodinâmica
Nesta tese serão discutidos alguns aspectos químicos, fotoquímicos e fotofísicos importantes no desenvolvimento de fotossensibilizadores para aplicação em terapia fotodinâmica (TFD). Os estudos abrangeram a investigação de 29 espécies, sendo que 20 delas continham um anel porfirínico convencional e 9 eram porfirinas duplamente N-confusas. As prime
Publicado em: 2005
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8. Adiabatic differential scanning calorimetric study of divalent cation induced DNA - DPPC liposome formulation compacted for gene delivery
Complexes between nucleic acids and phospholipid vesicles have been developed as stable non-viral gene delivery vehicles. Currently employed approach uses positively charged lipid species and a helper zwitterionic lipid, the latter being applied for the stabilization of the whole complex. However, besides problematic steps during their preparation, cationic
Brazilian Archives of Biology and Technology. Publicado em: 2004-11
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9. Cationic bilayers over silica: adsorption and colloidal stability at low ionic strength / Bicamadas catiônicas em sílica: adsorção e estabilidade coloidal a baixa força iônica
The study of adsorption of model-membranes on the surface of solid partic1es is an important line of research in rapidly developing research areas such as biosensors design, building up of immunological kits or design ofbiocompatible materiais. In this work, interactions between hidrophilic silica particles and cationic liposomes made up of dioctadecyldimeth
Publicado em: 2003
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10. Interactions between cationic liposomes and drugs or biomolecules
Multiple uses for synthetic cationic liposomes composed of dioctadecyldimethylammonium bromide (DODAB) bilayer vesicles are presented. Drugs or biomolecules can be solubilized or incorporated in the cationic bilayers. The cationic liposomes themselves can act as antimicrobial agents causing death of bacteria and fungi at concentrations that barely affect mam
Anais da Academia Brasileira de Ciências. Publicado em: 2000-03
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11. Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice.
This study sought to determine whether angiogenic blood vessels in disease models preferentially bind and internalize cationic liposomes injected intravenously. Angiogenesis was examined in pancreatic islet cell tumors of RIP-Tag2 transgenic mice and chronic airway inflammation in Mycoplasma pulmonis-infected C3H/HeNCr mice. For comparison, physiological ang
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12. Multilamellar structures of DNA complexes with cationic liposomes.
Studies of DNA complexes with cationic liposomes are prompted by the search for nonviral DNA carriers for gene therapy. Recent experiments have identified a stable multilamellar phase in which ordered smectic layers of DNA alternate with cationic bilayers. In this paper we identify the forces governing DNA adsorption on cationic lamellae, including a membran