Cd4 Down Modulation
Mostrando 1-12 de 55 artigos, teses e dissertações.
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1. Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood
Lipopolysaccharide (LPS) activates neutrophils and monocytes, inducing a wide array of biological activities. LPS rough (R) and smooth (S) forms signal through Toll-like receptor 4 (TLR4), but differ in their requirement for CD14. Since the R-form LPS can interact with TLR4 independent of CD14 and the differential expression of CD14 on neutrophils and monocy
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-09
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2. Resposta de neutrófilos e monócitos do sangue periférico ao LPS de bactérias lisas e rugosas / Neutrophils and monocytes response to LPS from smooth and rough bacteria
Objective: To compare the biological action of R form and S form LPS in human peripheral blood neutrophils and monocytes. Methods: Cell surface receptors modulation, ROS and NO production were evaluated on monocytes and neutrophils in whole blood, and NF-êB activation was evaluated in isolated neutrophils by flow cytometry after incubation with R and S-LPS.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2008
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3. Estudo da relevância fisiológica da tioesterase humana II (hTE) na modulação de CD4 mediada pela proteína Nef do HIV 1
The down-modulation of CD4 receptor expression is one of the most important events during the HIV-1 infection. Among the three viral proteins involved in this process Nef, Env and Vpu, the first one is the most relevant. Results obtained by our group and others showed a clear relationship between the virus mediated receptor down-modulation, the increasing of
Publicado em: 2007
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4. Envolvimento de sinais co-estimulatórios na progressão das doenças periodontais humanas / Differential expression of costimulatory molecules in human periodontal diseases
Negative co-stimulatory signals mediated via cell surface molecules such as cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and programmed death-1 (PD-1) play a critical role in down-modulation immune responses and maintaining peripheral tolerance. Both CTLA-4 and PD-1 are induced on activated T cells, and these are involved in the immunopathogenesis of
Publicado em: 2007
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5. Effects of GM1 administration on autoimmune diabetes modulation and cytokines expression, Nerve Growth Factor and TrkA receptor in NOD mice (non obese diabetic) / Avaliação dos efeitos da administração do gangliosideo GM1 na modulação do diabetes mellitus autoimune e expressão de citocinas, Nerve Growth Factor e seu receptor TrkA em camundongos NOD (non obese diabetic)
The strain of NOD mice (non obese diabetic) spontaneously develops diabetes mellitus type 1 (DM-1) with strong similarity to the observed in humans. In this model, the diabetes manifestation occurs among 12th and 24th weeks of life, with presence of pancreas-specific autoantibodies. Great part of the cells are CD4+ and CD8+T cells, and even so NK cells, lymp
Publicado em: 2007
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6. Análise mutacional de alelos do vpu, exon 1 do rev e a seqüência do peptídeo sinal do env, isolados de pacientes em diferentes estágios clínicos da infecção pelo HIV-1
A diminuição da expressão do receptor CD4 da superfície da célula infectada é um dos mais importantes eventos durante a infecção pelo vírus da Imunodeficiência Adquirida (HIV-1). Três proteínas virais, Nef, Env e Vpu, participam neste processo, sugerindo que a remoção do receptor viral possui um papel crítico no ciclo de vida destes retrovíru
Publicado em: 2006
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7. PRECONDITIONING OF ORGAN DONORS WITH LOW LEVELS OF CARBON MONOXIDE REDUCES GRAFT IMMUNOGENICITY AND IMPROVES LONGTERM ALLOGRAFT FUNCTION
Background: Chronic rejection remains the major obstacle for successful transplantation, and to date there is no effective treatment. Events occurring prior to organ transplantation such as brain death, harvesting procedure, and ischemia-reperfusion injury lead to unspecific inflammatory damages danger signals - that increase graft immunogenicity and reduce
Publicado em: 2005
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8. Lentiviral Vectors Interfering with Virus-Induced CD4 Down-Modulation Potently Block Human Immunodeficiency Virus Type 1 Replication in Primary Lymphocytes
CD4 down-modulation is essential for the production of human immunodeficiency virus (HIV) infectious particles. Disease progression correlates with enhanced viral induced CD4 down-modulation, and a subset of long-term nonprogressors carry viruses defective in this function. Despite multiple pieces of evidence highlighting the importance of this function in v
American Society for Microbiology.
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9. Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules.
The entry of human immunodeficiency virus type 1 into cells proceeds via a fusion mechanism that is initiated by binding of the viral glycoprotein gp120-gp41 to its cellular receptor CD4. Species- and tissue-specific restrictions to viral entry suggested the participation of additional membrane components in the postbinding fusion events. In a previous study
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10. CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
The human immunodeficiency virus type 1 (HIV-1) genes vpu, env, and nef have all been implicated in modulating the levels of cell surface CD4 on infected cells. To quantitatively assess the relative contribution of each gene product to the regulation of CD4 during HIV infection of Jurkat T cells and peripheral blood mononuclear cells, we have developed an in
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11. CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
The human immunodeficiency virus type 1 (HIV-1) Nef protein is an important virulence factor. Nef has several functions, including down-modulation of CD4 and class I major histocompatibility complex cell surface expression, enhancement of virion infectivity, and stimulation of viral replication in peripheral blood mononuclear cells. Nef also increases HIV-1
American Society for Microbiology.
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12. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.
Human immunodeficiency virus type 1 (HIV-1) Nef is a myristylated protein with a relative molecular mass of 27 kDa, is localized to the cytoplasmic surfaces of cellular membranes, and has been reported to down-modulate CD4 in human T cells. To understand the mechanism of HIV-1 Nef-mediated down-modulation of cell surface CD4, we expressed Nef protein in huma