Cellular Adhesion Molecules
Mostrando 1-12 de 149 artigos, teses e dissertações.
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1. Update on the pathogenesis of vitiligo
Abstract Vitiligo is a complex disease whose pathogenesis results from the interaction of genetic components, metabolic factors linked to cellular oxidative stress, melanocyte adhesion to the epithelium, and immunity (innate and adaptive), which culminate in aggression against melanocytes. In vitiligo, melanocytes are more sensitive to oxidative damage, lead
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Development of VEGF-loaded PLGA matrices in association with mesenchymal stem cells for tissue engineering
The association of bioactive molecules, such as vascular endothelial growth factor (VEGF), with nanofibers facilitates their controlled release, which could contribute to cellular migration and differentiation in tissue regeneration. In this research, the influence of their incorporation on a polylactic-co-glycolic acid (PLGA) scaffold produced by electrospi
Braz J Med Biol Res. Publicado em: 07/08/2017
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3. Influence of the Paracoccidioides brasiliensis14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells
The fungal strain Paracoccidioides brasiliensisremains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the molecules that participate in this process remained unknown. Thus, this study evaluated the contribution of two P. brasiliensismolecules, the 14-3-3 and glycoprotein of 43 kDa proteins, which had been p
Mem. Inst. Oswaldo Cruz. Publicado em: 02/06/2015
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4. Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds
Surface modification techniques based on the grafting of chemical functional groups and immobilization of bioactive molecules have been used to improve biocompatibility and clinical performance of bioabsorbable scaffolds in tissue engineering and medicine regenerative applications. This study aimed at developing and characterizing a biomimetic surface to sti
Mat. Res.. Publicado em: 2014-12
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5. Role of the extracellular matrix in variations of invasive pathways in lung cancers
Among the most common features of highly invasive tumors, such as lung adenocarcinomas (AD) and squamous cell carcinomas (SqCC), is the massive degradation of the extracellular matrix. The remarkable qualitative and quantitative modifications of hyaluronidases (HAases), hyaluronan synthases (HAS), E-cadherin adhesion molecules, and the transforming growth fa
Braz J Med Biol Res. Publicado em: 11/01/2013
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6. Avaliação da participação de células produtoras de IL-17 (TH17) na paracoccidioidomicose humana : efeito do tratamento com IL-17 e IL-23 sobre a atividade fungicida e capacidade migratória de neutrófilos / Evaluation of the participation of IL-17 producing Tcells (TH17) in human paracoccidioidomycosis : effect of the treatment with IL-17 and IL-23 on fungicidal activity and migratory capacity of neutrophils
A participação de células produtoras de IL-17 (Th17) na resposta imunológica contra infecções causadas por fungos tem sido recentemente objeto de grande interesse. A principal função da IL-17 é a ativação e atração de neutrófilos para o local de infecção. Lesões de pacientes com paracoccidioidomicose (PCM), a micose sistêmica mais important
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/01/2012
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7. Produção recombinante e caracterização de uma desintegrina da peçonha de Rhinocerophis alternatus (antiga Bothrops alternatus) com atividade antimetastática visando o desenvolvimento de um novo fármaco
This work presents the study of the effects of an RGD disintegrin from Rhinocerophis alternatus (ancient Bothrops alternatus) in key steps of the metastatic cascade. Disintegrins are cysteine-rich peptides, which have several biological activities related to cell-cell interaction and cell adhesion. The correct pairing of disulfide bonds exposes the adhesive
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2011
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8. Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock
BACKGROUND: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES: To investigate the protective effect of caffeic acid phenethye ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflamm
Brazilian Journal of Infectious Diseases. Publicado em: 2011-08
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9. The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer
During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There
International braz j urol. Publicado em: 2011-06
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10. Mecanismos celulares e moleculares de ação dos glicocorticóides endógenos sobre a mobilização de neutrófilos / Cellular and molecular mechanisms of action of endogenous glucocorticoids on the neutrophil mobilization
We have shown that endogenous glucocorticoids (GE) modulate the rolling and adhesion of neutrophils in vivo, mediating the expression of adhesion molecules on leukocytes and the endothelium. Additionally, the GE control neutrophil maturation in bone marrow and mobilization to peripheral blood. This work aimed to investigate the molecular and cellular mechani
Publicado em: 2010
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11. Papel do antidepressivo amitriptilina sobre a resposta inflamatória aguda em ratos / Role of the antidepressant amitriptyline in the acute inflammatory response in rats
Diversos estudos têm sugerido uma ação anti-inflamatória para o antidepressivo amitriptilina; a presente investigação pretende analisar os mecanismos envolvidos com esta resposta. Mais especificamente, o objetivo do presente estudo é avaliar os efeitos da amitriptilina sobre a resposta inflamatória induzida pela carragenina em ratos e investigar os p
Publicado em: 2010
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12. Clonagem, expressão, purificação e estudos estruturais dos domínios de reconhecimento de carboidratos (CRDs) da galectina-4 humana / Cloning, expression, purification and structural studies of the carbohydrate-recognition domains (CRDs) of human galectin-4
The galectin family comprises a group of lectins where the carbohydrate-recognition domains (CRDs) display specific affinity for ß-galactosides. They are widely distributed in normal and neoplasic cells of different organisms and are involved in a great diversity of cellular mechanisms. The galectins have been focus of recent studies, mainly for their invol
Publicado em: 2009