Cellular Death
Mostrando 1-12 de 899 artigos, teses e dissertações.
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1. Proadrenomedullin in Patients with Preserved Left Ventricular Systolic Function Undergoing Coronary Artery Bypass Grafting
Abstract Introduction: A potentially new marker of cardiovascular diseases — proadrenomedullin is the precursor of adrenomedullin, which is a multifunctional peptide hormone, produced in most of the tissues in response to cellular stress, ischemia, and hypoxia. Methods: Ninety-three people, aged 51-79 years, were included in the study. Exclusion criteria
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Pediatric Heart Transplant: Initial Experience in a Tertiary Center in Brazil
ABSTRACT Introduction: Pediatric heart transplantation is the definitive therapy for children with end-stage heart failure. This paper describes our initial experience in pediatric heart transplantation in a tertiary center in Brazil Methods: This is a historical prospective descriptive cohort study based on a review of the medical records of children unde
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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3. Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient
Abstract Friedreich’s ataxia (FRDA) is a progressive neuromuscular disorder caused by substantial decrease of mitochondrial protein frataxin responsible for biogenesis of iron-sulphur clusters and protection from oxidative damage. In this study, we investigated the antioxidant activities of a standardized aqueous extract from fruiting bodies of Hericium er
Food Sci. Technol. Publicado em: 2020-06
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4. Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model
Abstract The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DSBs) that accumulate due to the homologous recombination deficiency of BRCA-mutated cells. Such accumu
Genet. Mol. Biol.. Publicado em: 13/12/2019
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5. ADP-ribosylation: from molecular mechanisms to human disease
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribos
Genet. Mol. Biol.. Publicado em: 13/12/2019
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6. Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient
Abstract Friedreich’s ataxia (FRDA) is a progressive neuromuscular disorder caused by substantial decrease of mitochondrial protein frataxin responsible for biogenesis of iron-sulphur clusters and protection from oxidative damage. In this study, we investigated the antioxidant activities of a standardized aqueous extract from fruiting bodies of Hericium er
Food Sci. Technol. Publicado em: 13/12/2019
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7. Evaluation of cell damage and modulation of cytokines TNF-α, IL-6 and IL-10 in macrophages exposed to PpIX-mediated photodynamic therapy
Resumo Pouco se sabe se a morte celular induzida pela terapia fotodinâmica (PDT) compromete os macrófagos (MΦ), envolvidos nas respostas imunes induzidas pela PDT. Neste estudo, foram avaliados parâmetros de citotoxicidade dos MΦ mediada pela PDT e a produção de citocinas, frente à protoporfirina IX (PpIX). MΦ peritoneais de camundongos BALB/c foram
Braz. J. Biol.. Publicado em: 26/09/2019
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8. In situ DNA fragmentation during the re-establishment of desiccation tolerance in germinated seeds of Cedrela fissilis Vell.
Resumo: A desidratação é um procedimento necessário antes de expor as sementes ao armazenamento a longo prazo, mas isso está associado à lesão ligada ao metabolismo mediada por lesão celular. A fim de avaliar as alterações celulares durante o restabelecimento da tolerância à dessecação (TD) em sementes germinadas de C. fissilis e sua relação
J. Seed Sci.. Publicado em: 01/07/2019
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9. Dexmedetomidine preconditioning protects against lung injury in hemorrhagic shock rats
Resumo Justificativa e objetivos: Dexmedetomidina demonstrou efeitos protetores contra a lesão pulmonar in vitro. Neste estudo, investigamos se o pré-condicionamento com dexmedetomidina protege contra a lesão pulmonar em ratos com choque hemorrágico. Métodos: Ratos machos, Sprague-Dawley, foram aleatoriamente divididos em quatro grupos (n = 8): grupo
Rev. Bras. Anestesiol.. Publicado em: 25/04/2019
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10. Autophagy and intermittent fasting: the connection for cancer therapy?
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in canc
Clinics. Publicado em: 10/12/2018
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11. New insight on the relationship between lethal electrical fields versus cardiomyocyte orientation
Abstract Introduction Cardiovascular diseases represent a major cause of death world-wide and one of their greatest complications is the development of cardiac arrhythmias, in which ventricular fibrillation (VF) stands out as the most severe one. The only therapy that reverses VF is defibrillation. However defibrillatory shock is capable of killing heart c
Res. Biomed. Eng.. Publicado em: 13/09/2018
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12. Assesment of the Genotoxic Effect of the Diazinon on Root Cells of Allium cepa (L.)
ABSTRACT Organophosphorous pesticides (OPs) posses a great potential of acute toxicity for exposed animals and men. To evaluate the toxic potential of the organophosphate diazinon on root meristematic cells of Allium cepa L., was created two groups: In group 1 (control group), was not given any chemical. In group 2 (diazinon-treatment group), different doses
Braz. arch. biol. technol.. Publicado em: 06/08/2018