Central Depressant
Mostrando 1-12 de 88 artigos, teses e dissertações.
-
1. SIMPLE AND FAST DETERMINATION FOR GAMMA-HYDROXYBUTYRATE (GHB) IN URINE SAMPLE BY LLE AND GC-MS
Gamma-hydroxybutyrate (GHB) is a depressant of the central nervous system able to promote disinhibition, anterograde amnesia and its use is related to Drug-Facilitated Crimes (DFC). Urine is the biological matrix of choice for toxicological analysis in victims of rape and/or theft in suspected victims of DFC. The aim of this work was the development of a sim
Quím. Nova. Publicado em: 2021-02
-
2. Effect of (+)-dehydrofukinone on GABAA receptors and stress response in fish model
(+)-Dehydrofukinone (DHF) is a major component of the essential oil of Nectandra grandiflora (Lauraceae), and exerts a depressant effect on the central nervous system of fish. However, the neuronal mechanism underlying DHF action remains unknown. This study aimed to investigate the action of DHF on GABAA receptors using a silver catfish (Rhamdia quelen) mode
Braz J Med Biol Res. Publicado em: 27/11/2015
-
3. Neuropharmacological and genotoxic evaluation of ethanol extract from Erythrina falcata leaves, a plant used in Brazilian folk medicine
The aim of the present study was to determine neurobehavioral and genotoxic activities of ethanol extract of Erythrina falcata Benth., Fabaceae, leaves on rats. Animals were treated with ethanol extract of E. falcata (100, 300 or 500 mg/kg; i.p.) and the open field and elevated plus-maze tasks were used as behavioral models to investigate a possible effect o
Rev. bras. farmacogn.. Publicado em: 25/02/2013
-
4. Bioassay-guided evaluation of central nervous system effects of citronellal in rodents
The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaini
Revista Brasileira de Farmacognosia. Publicado em: 08/07/2011
-
5. Evaluation of central nervous system effects of Citrus limon essential oil in mice
The central nervous system (CNS) depressant and anticonvulsant activities of Citrus limon (L.) Osbeck, Rutaceae, essential oil (EO) were investigated in animal models. The EO (50, 100 and 150 mg/kg) injected by oral route (p.o.) in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to thirty days afte
Revista Brasileira de Farmacognosia. Publicado em: 20/05/2011
-
6. EFEITOS AGUDOS DA ASSOCIAÇÃO DE ETANOL E AMINOFILINA EM TESTES COMPORTAMENTAIS E NEUROQUÍMICOS EM CAMUNDONGOS / ACUTE EFFECTS OF ETHANOL AND ASSOCIATION TESTS IN aminophylline behavioral and neurochemical IN MICE
Ethanol effects in central nervous system (CNS) are due to its action in several neurotransmitter systems, changing the existing balance in inhibitory and excitatory pathways. Aminophylline, a methylxanthine with stimulant action, is an adenosine receptor antagonist, and actually used in treatment of asthma and consciousness recovery after long period of ane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/05/2010
-
7. EFEITOS AGUDOS DA ASSOCIAÇÃO DE ETANOL E MINOFILINA EM TESTES COMPORTAMENTAIS E NEUROQUÍMICOS EM CAMUNDONGOS / ACUTE EFFECTS OF THE ASSOCIATION OF ETHANOL ON TESTING AND AMINOPHYLLINE BEHAVIORAL AND NEUROCHEMICAL IN MICE
Ethanol effects in central nervous system (CNS) are due to its action in several neurotransmitter systems, changing the existing balance in inhibitory and excitatory pathways. Aminophylline, a methylxanthine with stimulant action, is an adenosine receptor antagonist, and actually used in treatment of asthma and consciousness recovery after long period of ane
Publicado em: 2010
-
8. Study of antinociceptive and antiinflammatory monoterpene a,b-epoxy-carvone and its effect on glutamatergic neurotransmission. / Estudo da atividade antinociceptiva e anti-inflamatória do monoterpeno a,b-Epoxi-carvona e seu efeito sobre a neurotransmissão glutamatérgica
The a, b-epoxy-carvone (EC) monoterpene is found in many essential oils from plants, but can also be obtained through organic synthesis from the R-(-)-carvone. Previous studies have demonstrated that this compound exerts depressant effect on central nervous system (CNS), and is also known to have anticonvulsant effects, antioxidant and antimicrobial activiti
Publicado em: 2010
-
9. Hypnotic effect of ecdysterone isolated from pfaffia glomerata (spreng.) pedersen / Efeito hipinótico de ecdisterona isolada de Pfaffi a glomerata (Spreng.) Pedersen
Neste trabalho foi avaliado, em roedores, o efeito depressor das frações clorofórmio (CHCl3), acetato de etila (EtOAc) e n-butanol, obtidas das partes subterrâneas de Pfaffi a glomerata, empregando-se o teste de tempo de sono barbitúrico como referência. Somente a fração lipofílica (CHCl3:EtOAc, 1:1, m/m) (i.p. 500 mg/kg; v.o. 1000 mg/kg) potenciou
Publicado em: 2010
-
10. Estudo comparativo dos efeitos dos Ãleos essenciais de Cymbopogon citratus e Cymbopogon winterianus (POACEAE) no sistema nervoso central de camundongos. / Comparative study of the effect of the essentials oils from Cymbopogon citratus and Cymbopogon winterianus (POACEAE) in the central nervous system of mice.
The main objective of the present work was to study in a comparative manner the effect of two essential oils, isolated from the leaves of Cymbopogon citratus (Cc) and Cymbopogon winterianus (Cw), medicinal herbs that belong to the Poaceae family and are common to the Northeast Region of Brazil. Their EOs effects were studied on the mice central nervous syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/12/2009
-
11. InvestigaÃÃo dos efeitos centrais e gastroprotetores do isopulegol em camundongos / Evaluation of the central nervous system and gastroprotective effects of isopulegol in mice.
Isopulegol is a monoterpene alcohol present in the essential oils of various plants, and has been used in the manufacture of fragrances with blossom compositions. In order to investigate its effects on animal models of CNS actions, isopulegol was administered to male Swiss mice at single doses of 25 and 50 mg/kg 30 (i.p.) or 60 min (p.o.) before the experime
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/08/2009
-
12. Efeito antinociceptivo do monoterpeno (S)-(-)-álcool perílico em camudongos
Essential oils are natural products with different applications, especially in the area therapeutic and cosmetic. Many essential oils exhibit a variety of pharmacological properties level of CNS, such as anxiolytic, anticonvulsant and antinociceptive. The influence of functional groups in the structures of these molecules in relation to psychopharmacological
Publicado em: 2009