Channel Segregation
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Multigenerational Brazilian family with malignant hyperthermia and a novel mutation in the RYR1 gene
Malignant hyperthermia (MH) is a pharmacogenetic disease triggered in susceptible individuals by the administration of volatile halogenated anesthetics and/or succinylcholine, leading to the development of a hypermetabolic crisis, which is caused by abnormal release of Ca2+ from the sarcoplasmic reticulum, through the Ca2+ release channel ryanodine receptor
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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2. A novel missense mutation p.L76P in the GJB2 gene causing nonsyndromic recessive deafness in a Brazilian family
Mutations in the GJB2 gene, encoding connexin 26 (Cx26), are a major cause of nonsyndromic recessive hearing loss in many countries. We report here on a novel point mutation in GJB2, p.L76P (c.227C>T), in compound heterozygosity with a c.35delG mutation, in two Brazilian sibs, one presenting mild and the other profound nonsyndromic neurosensorial hearing imp
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-02
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3. CHANNEL ALLOCATION COMPARATIVE ANALYSIS FOR TDMA TECHNOLOGY / ALOCAÇÃO DE CANAIS ANÁLISE COMPARATIVA PARA TECNOLOGIA TDMA
Fixed channel assignment -FCA- brings to the Cellular Communication Systems stability at the cost of the use of frequency planning, leading to low tolerance to traffic variability. Dynamic channel assignment -DCA- algorithms have been proposed by several authors in order to minimize these problems,incorporating flexibility to the system with respect to chann
Publicado em: 2002
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4. ANALYSIS OF THE PROBLEM OF TRAFFIC CHANNEL ASSIGNMENT IN MOBILE CELLULAR SYSTEMS / UMA ANÁLISE DO PROBLEMA DA ALOCAÇÃO DOS CANAIS DE TRÁFEGO EM SISTEMAS MÓVEIS CELULARES
In this work the problem of traffic channel assignment in móbile cellular systems is adressed. The use of more efficient assignment methods represents one of the main alternatives to enhance the performance of congested systems. Moreover, the ceaseless reduction of cell sizes requires the adoption of more flexible methods already proposed are presented, and
Publicado em: 1996
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5. Plant K+ channel alpha-subunits assemble indiscriminately.
In plants a large diversity of inwardly rectifying K+ channels (K(in) channels) has been observed between tissues and species. However, only three different types of voltage-dependent plant K+ uptake channel subfamilies have been cloned so far; they relate either to KAT1, AKT1, or AtKC1. To explore the mechanisms underlying the channel diversity, we investig
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6. N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor antagonist aminophosphonovaleric acid (APV), or to NMDA itself, to assess the influence of NMDA receptor/channels on the eye-specific segregation of retinal ganglion cell (RGC) terminals that occurs whenever two retinas innervate on
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7. Apical sorting of a voltage- and Ca2+-activated K+ channel α-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation
The voltage- and Ca2+-activated K+ (KV,Ca) channel is expressed in a variety of polarized epithelial cells seemingly displaying a tissue-dependent apical-to-basolateral regionalization, as revealed by electrophysiology. Using domain-specific biotinylation and immunofluorescence we show that the human channel KV,Ca α-subunit (human Slowpoke channel, h
The National Academy of Sciences.
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8. Cotranslational Partitioning of Nascent Prion Protein into Multiple Populations at the Translocation Channel
The decisive events that direct a single polypeptide such as the prion protein (PrP) to be synthesized at the endoplasmic reticulum in both fully translocated and transmembrane forms are poorly understood. In this study, we demonstrate that the topological heterogeneity of PrP is determined cotranslationally, while at the translocation channel. By evaluating
The American Society for Cell Biology.
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9. Modulation of DNA repair by mutations flanking the DNA channel through RNA polymerase
The RuvABC and RecBCD proteins promote rescue of stalled or broken DNA replication forks in Escherichia coli. Strains lacking these proteins cope poorly with DNA damage and have problems with chromosome segregation and cell division. We show how these difficulties are overcome to varying degrees by a sub-class of RNA polymerase mutations selected for their s
Oxford University Press.
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10. A Missense Mutation in a Highly Conserved Region of CASQ2 Is Associated with Autosomal Recessive Catecholamine-Induced Polymorphic Ventricular Tachycardia in Bedouin Families from Israel
Catecholamine-induced polymorphic ventricular tachycardia (PVT) is characterized by episodes of syncope, seizures, or sudden death, in response to physical activity or emotional stress. Two modes of inheritance have been described: autosomal dominant and autosomal recessive. Mutations in the ryanodine receptor 2 gene (RYR2), which encodes a cardiac sarcoplas
The American Society of Human Genetics.
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11. Cryptococcus neoformans Virulence Gene Discovery through Insertional Mutagenesis
Insertional mutagenesis was applied to Cryptococcus neoformans to identify genes associated with virulence attributes. Using biolistic transformation, we generated 4,300 nourseothricin (NAT)-resistant strains, of which 590 exhibited stable resistance. We focused on mutants with defects in established virulence factors and identified two with reduced growth a
American Society for Microbiology.
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12. Patch-clamp recording of amino acid-activated responses in "organotypic" slice cultures.
Patch-clamp recording techniques were used to study the properties of amino acid-activated channels in cultured "organotypic" slices from rat cerebellum and hippocampus. Hippocampal pyramidal cells responded to the three main glutamatergic agonists, N-methyl-D-aspartate (N-Me-D-Asp), quisqualate, and kainate, whereas Purkinje cells responded only to quisqual