Chaperone
Mostrando 1-12 de 1104 artigos, teses e dissertações.
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1. Fatty acid-binding protein 4 circulating levels in non-segmental vitiligo
Abstract Background: Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world’s population and is linked to inflammatory skin diseases including vitiligo. Fatty AcidBinding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is c
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Heterologous Expression of a Putative ClpC Chaperone Gene Leads to Induction of a Host Metabolite
Genome mining provides exciting opportunities for the discovery of natural products. However, in contrast to traditional bioassay-guided approaches, challenges of genome mining include poor or no expression of biosynthetic gene clusters (BGCs). Additionally, given that thousands of BGCs are now available through extensive genome sequencing, how does one sele
J. Braz. Chem. Soc.. Publicado em: 2019-03
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3. Micronutrients: Speculation on Inborn Errors, Nutrigenomics, Evolution, the Microbiome, and Nutritional Immunity
Abstract Many micronutrients or cofactors derived from micronutrients are highly reactive, hence their role in catalysis of reactions by enzymes. The concentration of cofactors has to be kept low to avoid unwanted reactions while allowing them to bind to the (apo)enzymes that need them. A new disorder causing B6-responsive epilepsy (proline synthetase cotran
J. inborn errors metab. screen.. Publicado em: 28/02/2019
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4. Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo
Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. His
J. Braz. Chem. Soc.. Publicado em: 2018-02
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5. Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions
Abstract Background Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin. Crotoxin is a non-covalent heterodimeric neurotoxin constituted of two subunits: an active phospholipase A2 and a chaperone p
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/12/2017
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6. Molecular cloning, characterization and expression analysis of a novel PDRG1 gene from black tiger shrimp (Penaeus monodon)
Abstract P53 And DNA Damage-Regulated Gene 1 (PDRG1) is a novel gene which plays an important role in chaperone-mediated protein folding. In the present study, the full-length complementary DNA (cDNA) sequence of the PDRG1 gene from Penaeus monodon (PmPDRG1) was cloned by the rapid amplification of cDNA ends (RACE) method. The cDNA of PmPDRG1 spans 1,613 bp,
Genet. Mol. Biol.. Publicado em: 02/03/2017
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7. HSP70 of Leishmania amazonensis alters resistance to different stresses and mitochondrial bioenergetics
The 70 kDa heat shock protein (HSP70) is a molecular chaperone that assists the parasite Leishmania in returning to homeostasis after being subjected to different types of stress during its life cycle. In the present study, we evaluated the effects of HSP70 transfection of L. amazonensis promastigotes (pTEX-HSP70) in terms of morphology, resistance, infectiv
Mem. Inst. Oswaldo Cruz. Publicado em: 10/06/2016
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8. Simultaneous Administration of Dexamethasone and Vitamin E Reversed Experimental Varicocele-induced Impact in testicular tissue in Rats; Correlation with Hsp70-2 Chaperone Expression
ABSTRACTPurpose:This study aimed to investigate the protective effects of isolated and co-administration of vitamin E (VitE) and dexamethasone (DEX) on varicocele (VCL)-induced damages in testicular tissue.Materials and Methods:Wistar rats were divided into five groups (n=6), including; control-sham, non-treated VCL-induced, VitE-treated VCL-induced (VitE, 1
Int. braz j urol.. Publicado em: 2015-08
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9. Heat Shock Protein Hspa5 Interacts with and Protects Tyrosinase Activity
In this study, heat shock protein, Hspa5 was cloned, expressed and purified subsequently confirmed that it interacted with the tyrosinase (TYR) in vitro. Then, using the crystal structure of the homologous protein from the bacteria as a template, a homology model of human TYR was constructed. This model was further applied to investigate the molecular dockin
Braz. arch. biol. technol.. Publicado em: 2015-08
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10. Rapid detection of Salmonella Typhi by loop-mediated isothermal amplification (LAMP) method
An in-house loop-mediated isothermal amplification (LAMP) reaction was established and evaluated for sensitivity and specificity in detecting the presence of Salmonella Typhi (S. Typhi) isolates from Kelantan, Malaysia. Three sets of primers consisting of two outer and 4 inner were designed based on locus STBHUCCB_38510 of chaperone PapD of S. Typhi genes. T
Braz. J. Microbiol.. Publicado em: 2014-12
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11. Estudos estruturais e funcionais da Hsp90 de Leishmania braziliensis e suas co-chaperonas p23 / Structural and functional studies of Leishmania braziliensis Hsp90 and its p23 co-chaperones
Molecular chaperones are proteins involved in proper folding of other proteins, and others important cellular functions, why they have been targeted for combating various diseases. The Hsp90 (82-96 kDa) are ubiquitous chaperones that interact with a wide range of client proteins. They are formed by three domains: N-terminal, central or middle (M), and C-term
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2012
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12. Estudos iniciais de ineraçãos da HSP90 através da caracterização funcioanl de um transgênico e biofísica de uma co-chaperona / Insights on Hsp90 chaperone interactions using transgenic and biophysical approaches
Chaperonas moleculares (Heat Shock proteins - HSPs) são componentes chave do sistema de controle de qualidade de proteínas (PQC - Protein Quality Control), que é essencial para a vida, sendo responsável por manter a homeostase proteica e a adequada função de diversas vias. Problemas no processo de enovelamento estão relacionados a doenças degenerativ
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2012