Chiral Drugs
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Coupling DLLME-CE for the Stereoselective Analysis of Venlafaxine and Its Main Metabolites after Biotransformation by Fungi
Fungal biotransformations have become very important in the study of chiral drugs because the reactions performed by these microorganisms may be enantioselective. However, analyses of analytes present in liquid culture medium have proved to be very difficult due to the complexity of this matrix. The aim of this work was to couple dispersive liquid-liquid mic
J. Braz. Chem. Soc.. Publicado em: 2015-09
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2. ENZYMATIC RESOLUTION OF ANTIDEPRESSANT DRUG PRECURSORS IN AN UNDERGRADUATE LABORATORY
The use of biocatalysts in synthetic chemistry is a conventional methodology for preparing enantiomerically enriched compounds. Despite this fact, the number of experiments in chemical teaching laboratories that demonstrate the potential of enzymes in synthetic organic chemistry is limited. We describe a laboratory experiment in which students synthesized a
Quím. Nova. Publicado em: 2015-02
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3. Catálise assimétrica no Brasil: desenvolvimento e potencialidades para o avanço da indústria química brasileira
The preparation of enantiomerically pure or enriched substances is of fundamental importance to pharmaceutical, food, agrochemical, and cosmetics industries and involves a growing market of hundreds of billions of dollars. However, most chemical processes used for their production are not environmentally friendly because in most cases, stoichiometric amounts
Quím. Nova. Publicado em: 2013
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4. Avaliação de técnicas miniaturizadas de preparação de amostras na análise enantiosseletiva de fármacos quirais com diferentes características ácido-base em meio microssomal e aplicação em estudos de metabolismo in vitro / Evaluation of microextraction techniques for sample preparation for the enantioselective analysis of chiral drugs with different acid-base characteristics in microsomal medium and application to in vitro metabolism studies
Neste trabalho, a microextração em fase líquida com membrana cilíndrica oca (HF-LPME), a microextração líquido-líquido dispersiva (DLLME) e a microextração em fase sólida na configuração de um filme delgado (SPME/TFME) foram empregadas como técnicas de microextração para a preparação de amostras microssomais no estudo de metabolismo in vitr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/04/2012
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5. Eletrophoretic and spectrometric characterization of Cinchona extracts of use phytoterapic and cosmetic / Caracterização eletroforética e espectrométrica de extratos de Cinchona de uso fitoterápico e cosmético
Every year, malaria kills about one million people. According to OMS, 3.3 billion people, half of the world population, are exposed to the disease, mostly in underdeveloped countries. The pharmaceuticals used in the treatment of malaria include: chloroquine, primaquine, quinine, mefloquine, doxyclyne, clindamicina and artemisin. The increased resistance of t
Publicado em: 2010
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6. Aplicação da microextração em fase liquida na análise de alguns fármacos antimaláricos e respectivos metabólitos em plasma / Application of liquid-phase microextration to the analysis of some antimalarial drugs and their metabolites in plasma
Currently, malaria is the main parasitic infection and shows worldwide distribution. Among therapeutic options used, chloroquine (CQ), mefloquine (MQ) and, more recently, artemether (ART) have been standing out. According to the literature, pharmacokinetic studies of these drugs have been hampered by the lack of proper methods of analysis in biological fluid
Publicado em: 2009
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7. Microextraction techniques applied to the stereoselective analysis of ibuprofen, hydroxychloroquine and their metabolites in human urine. / Técnicas de microextração aplicadas à análise estereosseletiva do ibuprofeno, da hidroxicloroquina e de seus metabólitos em urina
The stereoselective analysis has been standing out in several areas, and it is mainly present in the pharmaceutical industry, since many drugs are marketed as racemic mixtures. The stereoselective analysis employing high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) is very useful for the determination of enantiomers at very low
Publicado em: 2007
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8. Análise estereosseletiva da tioridazina e seus principais metabólitos: um estudo cinético de biotransformação empregando fungos / Stereoselective analysis of thioridazine and its major metabolites: a kinetic study of biotransformation by fungi
BORGES, K. B. Stereoselective analysis of thioridazine and its major metabolites: a kinetic study of biotransformation by fungi. 2006. 124p. Dissertation (Masters degree) Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, 2006. The interest in stereoselective biotransformation of drugs including the processe
Publicado em: 2006
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9. Análise enantiosseletiva de fármacos: contribuições da cromatografia líquida de alta eficiência e eletroforese capilar
The demand for analytical methods suitable for accurate and reproducible determination of drug enantiomers has increased significantly in the last years. High-performance liquid chromatography (HPLC) using chiral stationary phases and capillary electrophoresis (CE) are the most important techniques used for this purpose. In this paper, the fundamental aspect
Química Nova. Publicado em: 2005-08
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10. Separação do racemato N-Boc-Rolipram pelo processo cromatografico de leito movel simulado utilizando fase estacionaria quiral tris-(3,5-dimetilfenilcarbamato de celulose) suportada em silica
Chiral stationary phases (CSPs) have shown efficiency in racemate purification. Rolipram, (mais ou menos)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)- pyrrolidin-2-one, is an antidepressant with significant pharmacological properties. The main objective of this work was Rolipram purification in the Chiral Stationary Phase tris(3,5-dimethylphenylcarbamoyl) cellulo
Publicado em: 2005
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11. Análise enantiosseletiva da mirtazapina em plasma: comparação de métodos de preparação das amostras / Enantioselective analysis of plasma mirtazapine: comparison of sample preparation methods
The increased interest in enantioselective pharmacokinetic and pharmacodynamic properties of chiral drugs, aiming to establish the advantages in the production of estereochemically pure drugs, has led to the development of methods of analysis with low limits of quantification, selectivity and reproducibility, which are suitable to be used in kinetic disposit
Publicado em: 2005
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12. Estudo cinetico e de equilibrio na separação cromatografica dos enantiomeros da cetamina em triacetato de celulose microcristalina
There is a growing demand for efficient and low cost methods for the purification of the stereoisomers from chiral molecules, named enantiomers, in the manufacturing of drugs, flavours, pesticides and food additives, where these compounds are commonly encountered. Chrornatographic method is considered in nowadays an important alternative for the production o
Publicado em: 2003