Chiral Sulfoxide
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Synthesis of 8.O.4 neolignans, derivatives and active analogues in Leishmania / Sintese de neolignanas 8.O.4 , derivados e analogos ativos em Leishmania
Neolignans and lignans present significant biological and pharmacological activities. Chemically lignans are dimers derived from the oxidative coupling of cinnamic and/or cinnamyl alcohol, while neolignans derive from allyl and/or propenyl phenols. In this work, the synthesis of neolignans and correlated substances resulted from the condensation reactions be
Publicado em: 2009
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2. AplicaÃÃes de reagentes quirais de enxofre em catÃlise assimÃtrica e na sÃntese estereosseletiva de cetonas cÃclicas substituÃdas
This thesis describes the development of new methodologies for the use of chiral sulfur compounds, exploring their ability to transfer chiral information. The first methodology was based on the stereoselective transfer of ligands to α,β- unsaturated ketones mediated by organocuprates in a Michael addition reaction using (SR)- methyl-p-tolyl-sulfoxi
Publicado em: 2008
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3. Análise estereosseletiva da tioridazina e seus principais metabólitos: um estudo cinético de biotransformação empregando fungos / Stereoselective analysis of thioridazine and its major metabolites: a kinetic study of biotransformation by fungi
BORGES, K. B. Stereoselective analysis of thioridazine and its major metabolites: a kinetic study of biotransformation by fungi. 2006. 124p. Dissertation (Masters degree) Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, 2006. The interest in stereoselective biotransformation of drugs including the processe
Publicado em: 2006
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4. Complexos de Ãons lantanÃdeos como catalisadores em reaÃÃes orgÃnicas: aplicaÃÃo à sÃntese assimÃtrica de cianidrinas e Ãlcoois
O uso de complexos de lantanÃdeos quirais como novos catalisadores em sÃntese assimÃtrica tem sido extensivamente estudado na Ãltima dÃcada. Neste contexto, a busca por novos ligantes quirais e novos compostos de lantanÃdeos tem despertado grande interesse. Neste trabalho, ligantes quirais contendo grupamento sulfÃxidos e aminoÃcidos N-protegidos for
Publicado em: 2006
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5. Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450
The present study investigates the isoform(s) of cytochrome P450 (CYP) involved in the metabolism of albendazole sulfoxide (ASOX) to albendazole sulfone (ASON) in patients with neurocysticercosis using antipyrine as a multifunctional marker drug. The study was conducted on 11 patients with neurocysticercosis treated with a multiple dose regimen of albendazol
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-02
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6. An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction
An efficient asymmetric synthesis of a selective estrogen receptor modulator (SERM) that has a dihydrobenzoxathiin core structure bearing two stereogenic centers is reported. The stereogenic centers were established by an unprecedented chiral sulfoxide-directed stereospecific reduction of an α,β-unsaturated sulfoxide to the saturated sulfide in one step. S
National Academy of Sciences.
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7. Stereospecific sulfur oxidation of 7-methylthioxanthone-2-carboxylic acid by Calonectria decora.
Thin-layer chromatography was used to determine the ability of three microorganisms capable of sulfur oxygenation, including Aspergillus niger, Streptomyces armentosus subsp. armentosus, and Calonectria decora, to oxidize 7-methylthioxanthone-2-carboxylic acid to the corresponding sulfoxide in growing cultures. In addition, optical rotary dispersion, circula