Chka
Mostrando 1-2 de 2 artigos, teses e dissertações.
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1. Caracterização funcional de componentes da resposta ao dano DNA em Aspergillus nidulans: os genes chkA, chkB e ddbA / Functional Characterization of DNA damage response components in Aspergillus nidulans: the ddbA, chkA and chkB genes.
The constant exposure of different organisms to agents that damage the DNA structure, has provided the cells with repair mechanisms that are conserved during evolution. In mammal cells, the DNA damage repair pathways and the cell cycle checkpoint regulation act together to prevent cell cycle progression before the repair is performed avoiding mutation fixaxi
Publicado em: 2007
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2. Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice.
Previous studies using isolated tissues suggest that the colonic H, K-ATPase (cHKA), expressed in the colon and kidney, plays an important role in K+ conservation. To test the role of this pump in K+ homeostasis in vivo, we generated a cHKA-deficient mouse and analyzed its ability to retain K+ when fed a control or K+-free diet. When maintained on a control