Chlorpropamide
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Determination of chlorpropamide in plasma, using high-performance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS) and their application in a study of bioequivalence / Determinação de clorpropamida em plasma empregando empregando cromatografia liquida de alta eficiencia acoplada a espectrometria de massa sequencial (LC/MS/MS) e sua aplicação em um estudo de bioequivalencia
The relative bioavailability between two formulations of chlorpropamide was assessed on the dosage form tablet 250 mg, in healthy volunteers of both sexes. The study was conducted using an open, randomized, two-period crossover design with the 3-week washout interval. Thirty-six subjects were selected. The blood samples were collected at the time prior to do
Publicado em: 2007
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2. Polimorfismo da Clorpropamida investigado atravÃs de Espectroscopia Vibracional / Polymorphism of Chlorpropamide investigated through of the vibrational spectroscopy
Chlorpropamide (C10H13ClN2O3S, (1-[4-chlorobenzenesulphonyl]-3-propyl urea)) is a drug used to treat type II diabetes (non-dependent of insulin), especially when the diabetes can not be controlled by alimentary regimes. The polymorphism of this drug is widely documented exhibiting at least five crystalline forms. In this work, we present a vibrational study
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/03/2006
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3. Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism / Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALAD) no diabetes mellitus e no hipotireoidismo
The activity of Delta-Aminolevulinate Dehydratase (d-ALA-D) was analyzed in patients suffering from diabetes mellitus and primary hypothyroidism. Five groups of patients were studied: compensated diabetes mellitus, non-compensated diabetes mellitus, compensated hypothyroidism, non-compensated hypothyroidism and control group. The analysis of d-ALA-D in these
Publicado em: 2004
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4. Effect of sulfonylureas on triglyceride metabolism in the rat liver: possible role of the lysosomes in hepatic lipolysis.
It has been suggested previously that chlorpropamide and other hypoglycemic sulfonylureas interfere with hepatic triglyceride breakdown. Since ketogenesis from endogenous hepatic lipid stores is a measure of hepatic triglyceride hydrolysis, ketogenesis derived from endogenous lipids as well as ketogenesis derived from exogenously added isotopic oleate was de
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5. Inhibition of vasopressin-stimulated prostaglandin E biosynthesis by chlorpropamide in the toad urinary bladder. Mechanism of enhancement of vasopressin-stimulated water flow.
Chlorpropamide is known to enhance the water permeability response of the toad urinary bladder to vasopressin and to theophylline. In other studies, we have shown that prostaglandin E synthesis by the toad bladder inhibits the water permeability response to arginine vasopressin and to theophylline. In this study, the effect of chlorpropamide on vasopressin-,
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6. CHLORPROPAMIDE-INDUCED LEUCINE HYPOGLYCEMIA*
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7. Hyperinsulinaemic hypoglycaemia due to chlorpropamide-induced nesidioblastosis.
A 25 year old woman suffering from recurrent attacks of hypoglycaemia underwent a laparotomy for suspected insulinoma. No tumour was found, but histology showed islet cell hyperplasia and nesidioblastosis. Although these changes have been reported as a cause of hypoglycaemia in infants, they are only rarely the cause of hypoglycaemia in adults; in the presen
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8. Effects of sulfonylureas on the synthesis and secretion of plasminogen activator from bovine aortic endothelial cells.
The effects of sulfonylureas on the production of plasminogen activator (PA) and antiactivator (PAI) were investigated using bovine aortic endothelial cells. All compounds studied stimulated PA release (1.3- to 5.2-fold), with glipizide being the most potent, followed by tolazamide, chlorpropamide, and tolbutamide, in that order, while glyburide was the leas
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9. The effect of sulfonylurea drugs on rabbit myocardial contractility, canine purkinje fiber automaticity, and adenyl cyclase activity from rabbit and human hearts
Long-term clinical studies have associated tolbutamide therapy with an increased incidence of cardiovascular deaths. The effects of this and other sulfonylurea drugs on contractility and rate of isolated rabbit atria, automaticity of isolated dog Purkinje fibers, and adenyl cyclase activity in particulate preparations of rabbit and human hearts were studied.
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10. Generalization of a prototype intelligent hybrid system for hard gelatin capsule formulation development
The aim of this project was to expand a previously developed prototype expert network for use in the analysis of multiple biopharmaceutics classification system (BCS) class II drugs. The model drugs used were carbamazepine, chlorpropamide, diazepam, ibuprofen, ketoprofen, naproxen, and piroxicam. Recommended formulations were manufactured and tested for diss
Springer-Verlag.
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11. On the Mechanism of Lithium-Induced Diabetes Insipidus in Man and the Rat
The mechanism of lithium-induced diabetes insipidus was investigated in 96 patients and in a rat model. Polydipsia was reported by 40% and polyuria (more than 3 liter/day) by 12% of patients receiving lithium. Maximum concentrating ability after dehydration and vasopressin was markedly impaired in 10 polyuric patients and was reduced in 7 of 10 nonpolyuric p
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12. Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus.
To determine vasopressin (VP)-potentiating effect of chlorpropamide (CPMD), we studied the effect of CPMD in vivo and in vitro in kidneys and in specific tubule segments of rats with hypothalamic diabetes insipidus, homozygotes of the Brattleboro strain (DI rats). Rats on ad lib. water intake were treated with CPMD (20 mg/100 g body wt s.c. daily) for 7 d. W